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Complement Factor I MeSH Descriptor Data 2022


MeSH Heading
Complement Factor I
Tree Number(s)
D08.811.277.656.300.760.210
D08.811.277.656.959.350.210
D12.776.124.486.274.920.325.210
Unique ID
D017244
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D017244
Annotation
do not confuse with FACTOR I see FIBRINOGEN
Scope Note
A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein, respectively. It is a 66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF, or enzyme 3b inactivator.
Entry Term(s)
C3b Inactivator
C3b-C4b Inactivator
C4b-C3b-INA
C4bC3bINA
Complement 3b-Complement 4b Inactivator
Complement C4b-C3b Inactivator
Pharm Action
Complement Inactivating Agents
Registry Number
EC 3.4.21.45
Previous Indexing
Peptide Peptidohydrolases (1983-1987)
Serine Proteinases (1988-1992)
Public MeSH Note
93; COMPLEMENT FACTOR I was indexed under SERINE PROTEINASES 1988-92 & under PEPTIDE PEPTIDOHYDROLASES 1983-87
Online Note
use COMPLEMENT FACTOR I (NM) to search FACTOR I, C 3B INACTIVATOR 1983-92
History Note
93; was FACTOR I, C 3B INACTIVATOR (NM) 1983-92
Date Established
1993/01/01
Date of Entry
1992/05/07
Revision Date
2009/07/06
Complement Factor I Preferred
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