MeSH Browser

MeSH Heading: Epithelial Sodium Channels
Tree Number(s): D12.776.157.530.400.875.200; D12.776.543.550.450.875.200; D12.776.543.585.400.875.200
Unique ID: D053503
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053503
Scope Note: Sodium channels found on salt-reabsorbing EPITHELIAL CELLS that line the distal NEPHRON; the distal COLON; SALIVARY DUCTS; SWEAT GLANDS; and the LUNG. They are AMILORIDE-sensitive and play a critical role in the control of sodium balance, BLOOD VOLUME, and BLOOD PRESSURE.
Entry Term(s): ENaC (Epithelial Na+ Channel); ENaC alpha; ENaC beta; ENaC delta; ENaC gamma; Epithelial Amiloride-Sensitive Sodium Channel; Epithelial Sodium Channel; Epithelial Sodium Channel, alpha Subunit; Epithelial Sodium Channel, beta Subunit; Epithelial Sodium Channel, delta Subunit; Epithelial Sodium Channel, gamma Subunit; Epithelial Sodium Ion Channels; SCNN1 alpha Subunit; SCNN1 beta Subunit; SCNN1 delta Subunit; SCNN1 gamma Subunit; Sodium Channel, Nonvoltage-gated 1 Protein, alpha Subunit; Sodium Channel, Nonvoltage-gated 1 Protein, beta Subunit; Sodium Channel, Nonvoltage-gated 1 Protein, delta Subunit; Sodium Channel, Nonvoltage-gated 1 Protein, gamma Subunit
Registry Numbers: 0
Public MeSH Note: 2013; see EPITHELIAL SODIUM CHANNEL 2007-2012; EPITHELIAL SODIUM CHANNEL was indexed under SODIUM CHANNELS 1995-2006
History Note: 2013(1995)
Entry Combination: agonists:Epithelial Sodium Channel Agonists; antagonists & inhibitors:Epithelial Sodium Channel Blockers
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2016/07/01

Entry Combination: agonists:Epithelial Sodium Channel Agonists; antagonists & inhibitors:Epithelial Sodium Channel Blockers
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Channels [D12.776.157.530.400]
        
        Sodium Channels [D12.776.157.530.400.875]
        
        Acid Sensing Ion Channels [D12.776.157.530.400.875.050]
        
        Degenerin Sodium Channels [D12.776.157.530.400.875.100]
        
        Epithelial Sodium Channels [D12.776.157.530.400.875.200]
        
        Voltage-Gated Sodium Channels [D12.776.157.530.400.875.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Ion Channels [D12.776.543.550.450]
        
        Sodium Channels [D12.776.543.550.450.875]
        
        Acid Sensing Ion Channels [D12.776.543.550.450.875.050]
        
        Degenerin Sodium Channels [D12.776.543.550.450.875.100]
        
        Epithelial Sodium Channels [D12.776.543.550.450.875.200]
        
        Voltage-Gated Sodium Channels [D12.776.543.550.450.875.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Channels [D12.776.543.585.400]
        
        Sodium Channels [D12.776.543.585.400.875]
        
        Acid Sensing Ion Channels [D12.776.543.585.400.875.050]
        
        Degenerin Sodium Channels [D12.776.543.585.400.875.100]
        
        Epithelial Sodium Channels [D12.776.543.585.400.875.200]
        
        Voltage-Gated Sodium Channels [D12.776.543.585.400.875.750]

Epithelial Sodium Channels Preferred

Epithelial Sodium Channel, alpha Subunit Narrower

Epithelial Sodium Channel, beta Subunit Narrower

Epithelial Sodium Channel, gamma Subunit Narrower

Epithelial Sodium Channel, delta Subunit Narrower

Epithelial Sodium Channels MeSH Descriptor Data 2025