Chemokine CXCL12 MeSH Descriptor Data 2025

MeSH Heading: Chemokine CXCL12
Tree Number(s): D12.644.276.374.200.120.600; D12.776.467.374.200.120.600; D23.125.300.120.600; D23.469.200.120.600; D23.529.374.200.120.600
Unique ID: D054377
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054377
Scope Note: A CXC chemokine that is chemotactic for T-LYMPHOCYTES and MONOCYTES. It has specificity for CXCR4 RECEPTORS. Two isoforms of CXCL12 are produced by alternative mRNA splicing.
Entry Term(s): CXCL12 Chemokine; Chemokine (C-X-C Motif) Ligand 12; Pre-B-Cell Growth-Stimulating Factor; SDF-1alpha; SDF-1beta; SDF1-3'A; Stromal Cell-Derived Factor 1; Stromal Cell-Derived Factor-1alpha; Stromal Cell-Derived Factor-1beta
Public MeSH Note: 2008; CXCL12 CHEMOKINE (now CHEMOKINE CXCL12) was indexed under CHEMOKINES, CXC 1993-2007; STROMAL CELL-DERIVED FACTOR-1BETA was indexed under CYTOKINES 2001-2007
History Note: 2008(1993)
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2015/11/23

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]
    - Cytokines [D12.644.276.374]
      - Chemokines [D12.644.276.374.200]
        
        Chemokines, CXC [D12.644.276.374.200.120]
        
        Chemokine CXCL1 [D12.644.276.374.200.120.050]
        
        Chemokine CXCL16 [D12.644.276.374.200.120.075]
        
        Chemokine CXCL2 [D12.644.276.374.200.120.100]
        
        Chemokine CXCL5 [D12.644.276.374.200.120.250]
        
        Chemokine CXCL6 [D12.644.276.374.200.120.300]
        
        Chemokine CXCL9 [D12.644.276.374.200.120.450]
        
        Chemokine CXCL10 [D12.644.276.374.200.120.500]
        
        Chemokine CXCL11 [D12.644.276.374.200.120.550]
        
        Chemokine CXCL12 [D12.644.276.374.200.120.600]
        
        Chemokine CXCL13 [D12.644.276.374.200.120.650]
        
        Interleukin-8 [D12.644.276.374.200.120.800]
        
        Platelet Factor 4 [D12.644.276.374.200.120.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - Cytokines [D12.776.467.374]
      - Chemokines [D12.776.467.374.200]
        
        Chemokines, CXC [D12.776.467.374.200.120]
        
        Chemokine CXCL1 [D12.776.467.374.200.120.050]
        
        Chemokine CXCL16 [D12.776.467.374.200.120.075]
        
        Chemokine CXCL2 [D12.776.467.374.200.120.100]
        
        Chemokine CXCL5 [D12.776.467.374.200.120.250]
        
        Chemokine CXCL6 [D12.776.467.374.200.120.300]
        
        Chemokine CXCL9 [D12.776.467.374.200.120.450]
        
        Chemokine CXCL10 [D12.776.467.374.200.120.500]
        
        Chemokine CXCL11 [D12.776.467.374.200.120.550]
        
        Chemokine CXCL12 [D12.776.467.374.200.120.600]
        
        Chemokine CXCL13 [D12.776.467.374.200.120.650]
        
        Interleukin-8 [D12.776.467.374.200.120.800]
        
        Platelet Factor 4 [D12.776.467.374.200.120.900]

Biological Factors [D23]
- Chemotactic Factors [D23.125]
  - Chemokines [D23.125.300]
    - Chemokines, CXC [D23.125.300.120]

Biological Factors [D23]
- Inflammation Mediators [D23.469]
  - Chemokines [D23.469.200]
    - Chemokines, CXC [D23.469.200.120]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]
  - Cytokines [D23.529.374]
    - Chemokines [D23.529.374.200]
      - Chemokines, CXC [D23.529.374.200.120]
        
        Chemokine CXCL1 [D23.529.374.200.120.050]
        
        Chemokine CXCL16 [D23.529.374.200.120.075]
        
        Chemokine CXCL2 [D23.529.374.200.120.100]
        
        Chemokine CXCL5 [D23.529.374.200.120.250]
        
        Chemokine CXCL6 [D23.529.374.200.120.300]
        
        Chemokine CXCL9 [D23.529.374.200.120.450]
        
        Chemokine CXCL10 [D23.529.374.200.120.500]
        
        Chemokine CXCL11 [D23.529.374.200.120.550]
        
        Chemokine CXCL12 [D23.529.374.200.120.600]
        
        Chemokine CXCL13 [D23.529.374.200.120.650]
        
        Interleukin-8 [D23.529.374.200.120.800]
        
        Platelet Factor 4 [D23.529.374.200.120.900]

Chemokine CXCL12 Preferred

Concept UI: M0219484
Scope Note: A CXC chemokine that is chemotactic for T-LYMPHOCYTES and MONOCYTES. It has specificity for CXCR4 RECEPTORS. Two isoforms of CXCL12 are produced by alternative mRNA splicing.
Terms: Chemokine CXCL12 Preferred Term
Term UI T687177
Date12/04/2006
LexicalTag ABX
ThesaurusID NLM (2008); Chemokine (C-X-C Motif) Ligand 12
Term UI T000887945
Date10/15/2015
LexicalTag ABX
ThesaurusID NLM (2017); Stromal Cell-Derived Factor 1
Term UI T259036
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2008); Pre-B-Cell Growth-Stimulating Factor
Term UI T259037
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2008); CXCL12 Chemokine
Term UI T670540
Date04/04/2006
LexicalTag ABX
ThesaurusID NLM (2008)

Stromal Cell-Derived Factor-1beta Narrower

SDF1-3'A Narrower

Stromal Cell-Derived Factor-1alpha Narrower

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