MeSH Browser

MeSH Heading: Interleukin-8
Tree Number(s): D12.644.276.374.200.120.800; D12.644.276.374.465.312; D12.776.467.374.200.120.800; D12.776.467.374.465.246; D23.125.300.120.800; D23.469.200.120.800; D23.529.374.200.120.800; D23.529.374.465.312
Unique ID: D016209
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016209
Scope Note: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.
Entry Version: IL 8
Entry Term(s): AMCF-I; Alveolar Macrophage Chemotactic Factor-I; Anionic Neutrophil-Activating Peptide; CXCL8 Chemokine; Chemokine CXCL8; Chemokines, CXCL8; Chemotactic Factor, Macrophage-Derived; Chemotactic Factor, Neutrophil; Chemotactic Factor, Neutrophil, Monocyte-Derived; Granulocyte Chemotactic Peptide-Interleukin-8; IL-8; IL8; Monocyte-Derived Neutrophil Chemotactic Factor; Neutrophil Activation Factor; Neutrophil-Activating Peptide, Lymphocyte-Derived; Neutrophil-Activating Peptide, Monocyte-Derived
Previous Indexing: Interleukins (1988-1990)
See Also: Neutrophil Activation
Public MeSH Note: 1991; ALVEOLAR MACROPHAGE CHEMOTACTIC FACTOR-I was indexed under CHEMOTACTIC FACTORS 1991-2007
History Note: 1991
Date Established: 1991/01/01
Date of Entry: 1990/04/24
Revision Date: 2015/04/15

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]
    - Cytokines [D12.644.276.374]
      - Chemokines [D12.644.276.374.200]
        
        Chemokines, CXC [D12.644.276.374.200.120]
        
        Chemokine CXCL1 [D12.644.276.374.200.120.050]
        
        Chemokine CXCL16 [D12.644.276.374.200.120.075]
        
        Chemokine CXCL2 [D12.644.276.374.200.120.100]
        
        Chemokine CXCL5 [D12.644.276.374.200.120.250]
        
        Chemokine CXCL6 [D12.644.276.374.200.120.300]
        
        Chemokine CXCL9 [D12.644.276.374.200.120.450]
        
        Chemokine CXCL10 [D12.644.276.374.200.120.500]
        
        Chemokine CXCL11 [D12.644.276.374.200.120.550]
        
        Chemokine CXCL12 [D12.644.276.374.200.120.600]
        
        Chemokine CXCL13 [D12.644.276.374.200.120.650]
        
        Interleukin-8 [D12.644.276.374.200.120.800]
        
        Platelet Factor 4 [D12.644.276.374.200.120.900]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]
    - Cytokines [D12.644.276.374]
      - Interleukins [D12.644.276.374.465]
        
        Interleukin-1 [D12.644.276.374.465.010]
        
        Interleukin-2 [D12.644.276.374.465.021]
        
        Interleukin-21 [D12.644.276.374.465.027]
        
        Interleukin-3 [D12.644.276.374.465.032]
        
        Interleukin-4 [D12.644.276.374.465.186]
        
        Interleukin-5 [D12.644.276.374.465.202]
        
        Interleukin-6 [D12.644.276.374.465.224]
        
        Interleukin-7 [D12.644.276.374.465.246]
        
        Interleukin-8 [D12.644.276.374.465.312]
        
        Interleukin-9 [D12.644.276.374.465.377]
        
        Interleukin-10 [D12.644.276.374.465.510]
        
        Interleukin-11 [D12.644.276.374.465.511]
        
        Interleukin-12 [D12.644.276.374.465.512]
        
        Interleukin-13 [D12.644.276.374.465.513]
        
        Interleukin-15 [D12.644.276.374.465.515]
        
        Interleukin-16 [D12.644.276.374.465.516]
        
        Interleukin-17 [D12.644.276.374.465.517]
        
        Interleukin-18 [D12.644.276.374.465.518]
        
        Interleukin-23 [D12.644.276.374.465.759]
        
        Interleukin-27 [D12.644.276.374.465.800]
        
        Interleukin-33 [D12.644.276.374.465.850]
        
        Interleukin-22 [D12.644.276.374.465.925]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - Cytokines [D12.776.467.374]
      - Chemokines [D12.776.467.374.200]
        
        Chemokines, CXC [D12.776.467.374.200.120]
        
        Chemokine CXCL1 [D12.776.467.374.200.120.050]
        
        Chemokine CXCL16 [D12.776.467.374.200.120.075]
        
        Chemokine CXCL2 [D12.776.467.374.200.120.100]
        
        Chemokine CXCL5 [D12.776.467.374.200.120.250]
        
        Chemokine CXCL6 [D12.776.467.374.200.120.300]
        
        Chemokine CXCL9 [D12.776.467.374.200.120.450]
        
        Chemokine CXCL10 [D12.776.467.374.200.120.500]
        
        Chemokine CXCL11 [D12.776.467.374.200.120.550]
        
        Chemokine CXCL12 [D12.776.467.374.200.120.600]
        
        Chemokine CXCL13 [D12.776.467.374.200.120.650]
        
        Interleukin-8 [D12.776.467.374.200.120.800]
        
        Platelet Factor 4 [D12.776.467.374.200.120.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - Cytokines [D12.776.467.374]
      - Interleukins [D12.776.467.374.465]
        
        Interleukin-1 [D12.776.467.374.465.010]
        
        Interleukin-2 [D12.776.467.374.465.021]
        
        Interleukin-21 [D12.776.467.374.465.027]
        
        Interleukin-3 [D12.776.467.374.465.032]
        
        Interleukin-4 [D12.776.467.374.465.178]
        
        Interleukin-5 [D12.776.467.374.465.186]
        
        Interleukin-6 [D12.776.467.374.465.202]
        
        Interleukin-7 [D12.776.467.374.465.224]
        
        Interleukin-8 [D12.776.467.374.465.246]
        
        Interleukin-9 [D12.776.467.374.465.312]
        
        Interleukin-10 [D12.776.467.374.465.510]
        
        Interleukin-11 [D12.776.467.374.465.511]
        
        Interleukin-12 [D12.776.467.374.465.512]
        
        Interleukin-13 [D12.776.467.374.465.513]
        
        Interleukin-15 [D12.776.467.374.465.515]
        
        Interleukin-16 [D12.776.467.374.465.516]
        
        Interleukin-17 [D12.776.467.374.465.517]
        
        Interleukin-18 [D12.776.467.374.465.518]
        
        Interleukin-23 [D12.776.467.374.465.759]
        
        Interleukin-27 [D12.776.467.374.465.800]
        
        Interleukin-33 [D12.776.467.374.465.850]
        
        Interleukin-22 [D12.776.467.374.465.925]

Biological Factors [D23]
- Chemotactic Factors [D23.125]
  - Chemokines [D23.125.300]
    - Chemokines, CXC [D23.125.300.120]

Biological Factors [D23]
- Inflammation Mediators [D23.469]
  - Chemokines [D23.469.200]
    - Chemokines, CXC [D23.469.200.120]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]
  - Cytokines [D23.529.374]
    - Chemokines [D23.529.374.200]
      - Chemokines, CXC [D23.529.374.200.120]
        
        Chemokine CXCL1 [D23.529.374.200.120.050]
        
        Chemokine CXCL16 [D23.529.374.200.120.075]
        
        Chemokine CXCL2 [D23.529.374.200.120.100]
        
        Chemokine CXCL5 [D23.529.374.200.120.250]
        
        Chemokine CXCL6 [D23.529.374.200.120.300]
        
        Chemokine CXCL9 [D23.529.374.200.120.450]
        
        Chemokine CXCL10 [D23.529.374.200.120.500]
        
        Chemokine CXCL11 [D23.529.374.200.120.550]
        
        Chemokine CXCL12 [D23.529.374.200.120.600]
        
        Chemokine CXCL13 [D23.529.374.200.120.650]
        
        Interleukin-8 [D23.529.374.200.120.800]
        
        Platelet Factor 4 [D23.529.374.200.120.900]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]
  - Cytokines [D23.529.374]
    - Interleukins [D23.529.374.465]

Interleukin-8 Preferred

Concept UI: M0024750
Scope Note: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.
Terms: Interleukin-8 Preferred Term
Term UI T048217
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1991); IL-8
Term UI T048216
Date02/26/1990
LexicalTag ABB
ThesaurusID NLM (1991); IL8
Term UI T048224
Date03/05/1991
LexicalTag ABB
ThesaurusID NLM (1992); Monocyte-Derived Neutrophil Chemotactic Factor
Term UI T048212
Date02/23/1990
LexicalTag NON
ThesaurusID NLM (1991); Neutrophil Activation Factor
Term UI T048220
Date02/26/1990
LexicalTag NON
ThesaurusID NLM (1991); Neutrophil-Activating Peptide, Lymphocyte-Derived
Term UI T048221
Date02/26/1990
LexicalTag NON
ThesaurusID NLM (1991); Neutrophil-Activating Peptide, Monocyte-Derived
Term UI T048222
Date02/26/1990
LexicalTag NON
ThesaurusID NLM (1991); Alveolar Macrophage Chemotactic Factor-I
Term UI T217811
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2008); Anionic Neutrophil-Activating Peptide
Term UI T048209
Date04/16/1990
LexicalTag NON
ThesaurusID NLM (1991); Chemokine CXCL8
Term UI T687029
Date12/01/2006
LexicalTag ABX
ThesaurusID NLM (2008); Chemokines, CXCL8
Term UI T668877
Date03/17/2006
LexicalTag ABX
ThesaurusID NLM (2007); Chemotactic Factor, Macrophage-Derived
Term UI T048210
Date02/26/1990
LexicalTag NON
ThesaurusID NLM (1991); Chemotactic Factor, Neutrophil
Term UI T048211
Date02/26/1990
LexicalTag NON
ThesaurusID NLM (1991); Chemotactic Factor, Neutrophil, Monocyte-Derived
Term UI T048213
Date02/26/1990
LexicalTag NON
ThesaurusID NLM (1991); CXCL8 Chemokine
Term UI T668876
Date03/17/2006
LexicalTag ABX
ThesaurusID NLM (2007); Granulocyte Chemotactic Peptide-Interleukin-8
Term UI T048215
Date02/23/1990
LexicalTag NON
ThesaurusID NLM (1991); AMCF-I
Term UI T217810
Date01/01/1955
LexicalTag ABB
ThesaurusID NLM (2008)

Interleukin-8 MeSH Descriptor Data 2025