MeSH Browser

MeSH Heading: Interleukin-18
Tree Number(s): D12.644.276.374.465.518; D12.776.467.374.465.518; D23.529.374.465.518
Unique ID: D020382
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020382
Scope Note: A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.
Entry Term(s): IFN-gamma Inducing Factor; IFN-gamma-Inducing Factor; IL-18; IL18; Interferon-gamma Inducing Factor; Interferon-gamma-Inducing Factor
Previous Indexing: Cytokines (1995-1998)
Public MeSH Note: 1999; INTERFERON-GAMMA INDUCING FACTOR (now INTERLEUKIN-18) was indexed under CYTOKINES 1995-1998
History Note: 1999; use INTERLEUKIN-18 (NM) 1995-1998
Date Established: 1999/01/01
Date of Entry: 2024/08/09
Revision Date: 2024/05/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0030026
Scope Note: A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.
Terms: Interleukin-18 Preferred Term
Term UI T060226
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1999); IFN-gamma Inducing Factor
Term UI T060221
Date05/20/1998
LexicalTag NON
ThesaurusID NLM (1999); IFN-gamma-Inducing Factor
Term UI T060222
Date05/20/1998
LexicalTag NON
ThesaurusID NLM (1999); IL-18
Term UI T060225
Date03/06/1998
LexicalTag ABB
ThesaurusID NLM (1999); IL18
Term UI T060227
Date03/06/1998
LexicalTag ABB
ThesaurusID NLM (1999); Interferon-gamma Inducing Factor
Term UI T060223
Date03/06/1998
LexicalTag NON
ThesaurusID NLM (1999); Interferon-gamma-Inducing Factor
Term UI T060224
Date03/06/1998
LexicalTag NON
ThesaurusID NLM (1999)

Interleukin-18 MeSH Descriptor Data 2025