MeSH Browser

MeSH Heading: Interleukin-21
Tree Number(s): D12.644.276.374.465.027; D12.776.467.374.465.027; D23.529.374.465.162
Unique ID: D000098546
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000098546
Scope Note: INTERLEUKINS that affect the differentiation and function of LYMPHOCYTES and MYELOID CELLS and regulate both IMMUNITY, INNATE and ADAPTIVE IMMUNITY. They are also involved in the expansion of NK CELLS.
Entry Term(s): IL-21; IL21; Interleukin 21
Registry Numbers: MKM3CA6LT1
Public MeSH Note: 2025; INTERLEUKIN-21 was indexed under INTERLEUKINS 2000-2024
History Note: 2025 (2000)
Date Introduced: 2025/01/01
Last Updated: 2025/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]
    - Cytokines [D12.644.276.374]
      - Interleukins [D12.644.276.374.465]
        
        Interleukin-1 [D12.644.276.374.465.010]
        
        Interleukin-2 [D12.644.276.374.465.021]
        
        Interleukin-21 [D12.644.276.374.465.027]
        
        Interleukin-3 [D12.644.276.374.465.032]
        
        Interleukin-4 [D12.644.276.374.465.186]
        
        Interleukin-5 [D12.644.276.374.465.202]
        
        Interleukin-6 [D12.644.276.374.465.224]
        
        Interleukin-7 [D12.644.276.374.465.246]
        
        Interleukin-8 [D12.644.276.374.465.312]
        
        Interleukin-9 [D12.644.276.374.465.377]
        
        Interleukin-10 [D12.644.276.374.465.510]
        
        Interleukin-11 [D12.644.276.374.465.511]
        
        Interleukin-12 [D12.644.276.374.465.512]
        
        Interleukin-13 [D12.644.276.374.465.513]
        
        Interleukin-15 [D12.644.276.374.465.515]
        
        Interleukin-16 [D12.644.276.374.465.516]
        
        Interleukin-17 [D12.644.276.374.465.517]
        
        Interleukin-18 [D12.644.276.374.465.518]
        
        Interleukin-23 [D12.644.276.374.465.759]
        
        Interleukin-24 [D12.644.276.374.465.780]
        
        Interleukin-27 [D12.644.276.374.465.800]
        
        Interleukin-33 [D12.644.276.374.465.850]
        
        Interleukin-22 [D12.644.276.374.465.925]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - Cytokines [D12.776.467.374]
      - Interleukins [D12.776.467.374.465]
        
        Interleukin-1 [D12.776.467.374.465.010]
        
        Interleukin-2 [D12.776.467.374.465.021]
        
        Interleukin-21 [D12.776.467.374.465.027]
        
        Interleukin-3 [D12.776.467.374.465.032]
        
        Interleukin-4 [D12.776.467.374.465.178]
        
        Interleukin-5 [D12.776.467.374.465.186]
        
        Interleukin-6 [D12.776.467.374.465.202]
        
        Interleukin-7 [D12.776.467.374.465.224]
        
        Interleukin-8 [D12.776.467.374.465.246]
        
        Interleukin-9 [D12.776.467.374.465.312]
        
        Interleukin-10 [D12.776.467.374.465.510]
        
        Interleukin-11 [D12.776.467.374.465.511]
        
        Interleukin-12 [D12.776.467.374.465.512]
        
        Interleukin-13 [D12.776.467.374.465.513]
        
        Interleukin-15 [D12.776.467.374.465.515]
        
        Interleukin-16 [D12.776.467.374.465.516]
        
        Interleukin-17 [D12.776.467.374.465.517]
        
        Interleukin-18 [D12.776.467.374.465.518]
        
        Interleukin-23 [D12.776.467.374.465.759]
        
        Interleukin-24 [D12.776.467.374.465.780]
        
        Interleukin-27 [D12.776.467.374.465.800]
        
        Interleukin-33 [D12.776.467.374.465.850]
        
        Interleukin-22 [D12.776.467.374.465.925]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]
  - Cytokines [D23.529.374]
    - Interleukins [D23.529.374.465]

Interleukin-21 Preferred

Concept UI: M0373673
Registry Numbers: MKM3CA6LT1
Scope Note: INTERLEUKINS that affect the differentiation and function of LYMPHOCYTES and MYELOID CELLS and regulate both IMMUNITY, INNATE and ADAPTIVE IMMUNITY. They are also involved in the expansion of NK CELLS.
Terms: Interleukin-21 Preferred Term
Term UI T001141252
Date12/07/2023
LexicalTag NON
ThesaurusID NLM (2025); IL-21
Term UI T533575
Date02/25/2003
LexicalTag NON
ThesaurusID NLM (2003); IL21
Term UI T429891
Date11/29/2000
LexicalTag NON
ThesaurusID NLM (2000); Interleukin 21
Term UI T001141253
Date12/07/2023
LexicalTag NON
ThesaurusID NLM (2025)

Interleukin-21 MeSH Descriptor Data 2026