MeSH Browser

MeSH Heading: Interleukin-12
Tree Number(s): D12.644.276.374.465.512; D12.776.467.374.465.512; D23.529.374.465.512
Unique ID: D018664
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D018664
Scope Note: A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.
Entry Term(s): Cytotoxic Lymphocyte Maturation Factor; Edodekin Alfa; IL 12; IL-12; IL-12 p70; IL12; Interleukin 12; Interleukin-12 p70; Natural Killer Cell Stimulatory Factor
Pharm Action: Adjuvants, Immunologic
Angiogenesis Inhibitors
Registry Numbers: 187348-17-0; 0
Previous Indexing: Interleukins (1991-1994)
See Also: Immunity, Cellular; Ustekinumab
Public MeSH Note: 1995; INTERLEUKIN 12 was indexed under INTERLEUKINS 1991-1994; INTERLEUKIN-12 P70 was indexed under INTERLEUKIN-12 2003-2006
History Note: 1995 (1991)
Date Established: 1995/01/01
Date of Entry: 1994/04/19
Revision Date: 2018/10/10

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]
    - Cytokines [D12.644.276.374]
      - Interleukins [D12.644.276.374.465]
        
        Interleukin-1 [D12.644.276.374.465.010]
        
        Interleukin-2 [D12.644.276.374.465.021]
        
        Interleukin-21 [D12.644.276.374.465.027]
        
        Interleukin-3 [D12.644.276.374.465.032]
        
        Interleukin-4 [D12.644.276.374.465.186]
        
        Interleukin-5 [D12.644.276.374.465.202]
        
        Interleukin-6 [D12.644.276.374.465.224]
        
        Interleukin-7 [D12.644.276.374.465.246]
        
        Interleukin-8 [D12.644.276.374.465.312]
        
        Interleukin-9 [D12.644.276.374.465.377]
        
        Interleukin-10 [D12.644.276.374.465.510]
        
        Interleukin-11 [D12.644.276.374.465.511]
        
        Interleukin-12 [D12.644.276.374.465.512]
        
        Interleukin-12 Subunit p35 [D12.644.276.374.465.512.249]
        
        Interleukin-12 Subunit p40 [D12.644.276.374.465.512.500]
        
        Interleukin-13 [D12.644.276.374.465.513]
        
        Interleukin-15 [D12.644.276.374.465.515]
        
        Interleukin-16 [D12.644.276.374.465.516]
        
        Interleukin-17 [D12.644.276.374.465.517]
        
        Interleukin-18 [D12.644.276.374.465.518]
        
        Interleukin-23 [D12.644.276.374.465.759]
        
        Interleukin-27 [D12.644.276.374.465.800]
        
        Interleukin-33 [D12.644.276.374.465.850]
        
        Interleukin-22 [D12.644.276.374.465.925]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - Cytokines [D12.776.467.374]
      - Interleukins [D12.776.467.374.465]
        
        Interleukin-1 [D12.776.467.374.465.010]
        
        Interleukin-2 [D12.776.467.374.465.021]
        
        Interleukin-21 [D12.776.467.374.465.027]
        
        Interleukin-3 [D12.776.467.374.465.032]
        
        Interleukin-4 [D12.776.467.374.465.178]
        
        Interleukin-5 [D12.776.467.374.465.186]
        
        Interleukin-6 [D12.776.467.374.465.202]
        
        Interleukin-7 [D12.776.467.374.465.224]
        
        Interleukin-8 [D12.776.467.374.465.246]
        
        Interleukin-9 [D12.776.467.374.465.312]
        
        Interleukin-10 [D12.776.467.374.465.510]
        
        Interleukin-11 [D12.776.467.374.465.511]
        
        Interleukin-12 [D12.776.467.374.465.512]
        
        Interleukin-12 Subunit p35 [D12.776.467.374.465.512.249]
        
        Interleukin-12 Subunit p40 [D12.776.467.374.465.512.500]
        
        Interleukin-13 [D12.776.467.374.465.513]
        
        Interleukin-15 [D12.776.467.374.465.515]
        
        Interleukin-16 [D12.776.467.374.465.516]
        
        Interleukin-17 [D12.776.467.374.465.517]
        
        Interleukin-18 [D12.776.467.374.465.518]
        
        Interleukin-23 [D12.776.467.374.465.759]
        
        Interleukin-27 [D12.776.467.374.465.800]
        
        Interleukin-33 [D12.776.467.374.465.850]
        
        Interleukin-22 [D12.776.467.374.465.925]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]
  - Cytokines [D23.529.374]
    - Interleukins [D23.529.374.465]

Interleukin-12 Preferred

Concept UI: M0027969
Registry Numbers: 187348-17-0
Scope Note: A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.
Terms: Interleukin-12 Preferred Term
Term UI T055562
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1995); Interleukin 12
Term UI T055561
Date03/08/1994
LexicalTag NON
ThesaurusID NLM (1995); Natural Killer Cell Stimulatory Factor
Term UI T055563
Date01/24/1994
LexicalTag NON
ThesaurusID NLM (1995); IL12
Term UI T055566
Date01/24/1994
LexicalTag ABB
ThesaurusID NLM (1995); IL 12
Term UI T373474
Date11/04/1999
LexicalTag ABB
ThesaurusID NLM (2000); IL-12 p70
Term UI T550497
Date09/10/2003
LexicalTag ABB
ThesaurusID NLM (2007); Interleukin-12 p70
Term UI T669076
Date03/21/2006
LexicalTag ABX
ThesaurusID NLM (2007); IL-12
Term UI T055565
Date01/24/1994
LexicalTag ABB
ThesaurusID NLM (1995); Cytotoxic Lymphocyte Maturation Factor
Term UI T669102
Date03/21/2006
LexicalTag NON
ThesaurusID NLM (2007)

Edodekin Alfa Related

Interleukin-12 MeSH Descriptor Data 2025