MeSH Browser

MeSH Heading: Interleukin-1
Tree Number(s): D12.644.276.374.465.010; D12.644.276.374.500.400; D12.776.467.374.465.010; D12.776.467.374.500.400; D23.529.374.465.131; D23.529.374.500.400
Unique ID: D007375
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007375
Scope Note: A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
Entry Term(s): Epidermal Cell Derived Thymocyte-Activating Factor; IL-1; Interleukin I; Lymphocyte-Activating Factor; Macrophage Cell Factor; T Helper Factor
Previous Indexing: Lymphocytes (1966-1971); Lymphocyte Transformation (1972-1982); Lymphokines (1974-1982); Macrophages (1966-1982); Toxins (1966-1973)
See Also: Receptors, Interleukin-1
Public MeSH Note: 1990; see INTERLEUKIN 1 1983-1989
History Note: 1990(1983)
Date Established: 1983/01/01
Date of Entry: 1982/04/29
Revision Date: 2015/04/15

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]
    - Cytokines [D12.644.276.374]
      - Interleukins [D12.644.276.374.465]
        
        Interleukin-1 [D12.644.276.374.465.010]
        
        Interleukin-1alpha [D12.644.276.374.465.010.300]
        
        Interleukin-1beta [D12.644.276.374.465.010.600]
        
        Interleukin-2 [D12.644.276.374.465.021]
        
        Interleukin-21 [D12.644.276.374.465.027]
        
        Interleukin-3 [D12.644.276.374.465.032]
        
        Interleukin-4 [D12.644.276.374.465.186]
        
        Interleukin-5 [D12.644.276.374.465.202]
        
        Interleukin-6 [D12.644.276.374.465.224]
        
        Interleukin-7 [D12.644.276.374.465.246]
        
        Interleukin-8 [D12.644.276.374.465.312]
        
        Interleukin-9 [D12.644.276.374.465.377]
        
        Interleukin-10 [D12.644.276.374.465.510]
        
        Interleukin-11 [D12.644.276.374.465.511]
        
        Interleukin-12 [D12.644.276.374.465.512]
        
        Interleukin-13 [D12.644.276.374.465.513]
        
        Interleukin-15 [D12.644.276.374.465.515]
        
        Interleukin-16 [D12.644.276.374.465.516]
        
        Interleukin-17 [D12.644.276.374.465.517]
        
        Interleukin-18 [D12.644.276.374.465.518]
        
        Interleukin-23 [D12.644.276.374.465.759]
        
        Interleukin-27 [D12.644.276.374.465.800]
        
        Interleukin-33 [D12.644.276.374.465.850]
        
        Interleukin-22 [D12.644.276.374.465.925]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]
    - Cytokines [D12.644.276.374]
      - Monokines [D12.644.276.374.500]
        
        Interleukin-1 [D12.644.276.374.500.400]
        
        Interleukin-1alpha [D12.644.276.374.500.400.300]
        
        Interleukin-1beta [D12.644.276.374.500.400.600]
        
        Tumor Necrosis Factor-alpha [D12.644.276.374.500.800]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - Cytokines [D12.776.467.374]
      - Interleukins [D12.776.467.374.465]
        
        Interleukin-1 [D12.776.467.374.465.010]
        
        Interleukin-1alpha [D12.776.467.374.465.010.300]
        
        Interleukin-1beta [D12.776.467.374.465.010.600]
        
        Interleukin-2 [D12.776.467.374.465.021]
        
        Interleukin-21 [D12.776.467.374.465.027]
        
        Interleukin-3 [D12.776.467.374.465.032]
        
        Interleukin-4 [D12.776.467.374.465.178]
        
        Interleukin-5 [D12.776.467.374.465.186]
        
        Interleukin-6 [D12.776.467.374.465.202]
        
        Interleukin-7 [D12.776.467.374.465.224]
        
        Interleukin-8 [D12.776.467.374.465.246]
        
        Interleukin-9 [D12.776.467.374.465.312]
        
        Interleukin-10 [D12.776.467.374.465.510]
        
        Interleukin-11 [D12.776.467.374.465.511]
        
        Interleukin-12 [D12.776.467.374.465.512]
        
        Interleukin-13 [D12.776.467.374.465.513]
        
        Interleukin-15 [D12.776.467.374.465.515]
        
        Interleukin-16 [D12.776.467.374.465.516]
        
        Interleukin-17 [D12.776.467.374.465.517]
        
        Interleukin-18 [D12.776.467.374.465.518]
        
        Interleukin-23 [D12.776.467.374.465.759]
        
        Interleukin-27 [D12.776.467.374.465.800]
        
        Interleukin-33 [D12.776.467.374.465.850]
        
        Interleukin-22 [D12.776.467.374.465.925]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - Cytokines [D12.776.467.374]
      - Monokines [D12.776.467.374.500]
        
        Interleukin-1 [D12.776.467.374.500.400]
        
        Interleukin-1alpha [D12.776.467.374.500.400.300]
        
        Interleukin-1beta [D12.776.467.374.500.400.600]
        
        Tumor Necrosis Factor-alpha [D12.776.467.374.500.800]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]
  - Cytokines [D23.529.374]
    - Interleukins [D23.529.374.465]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]
  - Cytokines [D23.529.374]
    - Monokines [D23.529.374.500]
      - Interleukin-1 [D23.529.374.500.400]
        
        Interleukin-1alpha [D23.529.374.500.400.300]
        
        Interleukin-1beta [D23.529.374.500.400.600]
      - Tumor Necrosis Factor-alpha [D23.529.374.500.800]

Interleukin-1 Preferred

Concept UI: M0011503
Scope Note: A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
Terms: Interleukin-1 Preferred Term
Term UI T022104
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1983); Epidermal Cell Derived Thymocyte-Activating Factor
Term UI T022098
Date09/09/1983
LexicalTag NON
ThesaurusID UNK (19XX); IL-1
Term UI T022109
Date05/25/1989
LexicalTag ABB
ThesaurusID NLM (1990); Interleukin I
Term UI T022110
Date03/16/1990
LexicalTag ABB
ThesaurusID NLM (1991); Lymphocyte-Activating Factor
Term UI T022105
Date04/29/1982
LexicalTag NON
ThesaurusID UNK (19XX); Macrophage Cell Factor
Term UI T022107
Date04/29/1982
LexicalTag NON
ThesaurusID UNK (19XX); T Helper Factor
Term UI T022108
Date10/02/1984
LexicalTag NON
ThesaurusID UNK (19XX)

Interleukin-1 MeSH Descriptor Data 2025