MeSH Browser

MeSH Heading: Interleukin-4
Tree Number(s): D12.644.276.374.465.186; D12.776.467.374.465.178; D23.529.374.465.186
Unique ID: D015847
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015847
Scope Note: A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
Entry Term(s): B Cell Stimulatory Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulatory Factor 1; B-Cell Stimulatory Factor-1; BCGF-1; BSF-1; Binetrakin; IL-4; IL4; MCGF-2; Mast Cell Growth Factor-2
Pharm Action: Adjuvants, Immunologic
Antineoplastic Agents
Antirheumatic Agents
Previous Indexing: Interleukins (1988-1989); Lymphokines (1974-1987)
See Also: Histocompatibility Antigens Class II
Public MeSH Note: 90; B-CELL GROWTH FACTOR was see INTERLEUKIN-4 1990-96
Online Note: use INTERLEUKIN-4 to search B-CELL GROWTH FACTOR 1990-96
History Note: 90; B-CELL GROWTH FACTOR was see INTERLEUKIN-4 1990-96
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2015/04/15

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]
    - Cytokines [D12.644.276.374]
      - Interleukins [D12.644.276.374.465]
        
        Interleukin-1 [D12.644.276.374.465.010]
        
        Interleukin-2 [D12.644.276.374.465.021]
        
        Interleukin-21 [D12.644.276.374.465.027]
        
        Interleukin-3 [D12.644.276.374.465.032]
        
        Interleukin-4 [D12.644.276.374.465.186]
        
        Interleukin-5 [D12.644.276.374.465.202]
        
        Interleukin-6 [D12.644.276.374.465.224]
        
        Interleukin-7 [D12.644.276.374.465.246]
        
        Interleukin-8 [D12.644.276.374.465.312]
        
        Interleukin-9 [D12.644.276.374.465.377]
        
        Interleukin-10 [D12.644.276.374.465.510]
        
        Interleukin-11 [D12.644.276.374.465.511]
        
        Interleukin-12 [D12.644.276.374.465.512]
        
        Interleukin-13 [D12.644.276.374.465.513]
        
        Interleukin-15 [D12.644.276.374.465.515]
        
        Interleukin-16 [D12.644.276.374.465.516]
        
        Interleukin-17 [D12.644.276.374.465.517]
        
        Interleukin-18 [D12.644.276.374.465.518]
        
        Interleukin-23 [D12.644.276.374.465.759]
        
        Interleukin-27 [D12.644.276.374.465.800]
        
        Interleukin-33 [D12.644.276.374.465.850]
        
        Interleukin-22 [D12.644.276.374.465.925]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - Cytokines [D12.776.467.374]
      - Interleukins [D12.776.467.374.465]
        
        Interleukin-1 [D12.776.467.374.465.010]
        
        Interleukin-2 [D12.776.467.374.465.021]
        
        Interleukin-21 [D12.776.467.374.465.027]
        
        Interleukin-3 [D12.776.467.374.465.032]
        
        Interleukin-4 [D12.776.467.374.465.178]
        
        Interleukin-5 [D12.776.467.374.465.186]
        
        Interleukin-6 [D12.776.467.374.465.202]
        
        Interleukin-7 [D12.776.467.374.465.224]
        
        Interleukin-8 [D12.776.467.374.465.246]
        
        Interleukin-9 [D12.776.467.374.465.312]
        
        Interleukin-10 [D12.776.467.374.465.510]
        
        Interleukin-11 [D12.776.467.374.465.511]
        
        Interleukin-12 [D12.776.467.374.465.512]
        
        Interleukin-13 [D12.776.467.374.465.513]
        
        Interleukin-15 [D12.776.467.374.465.515]
        
        Interleukin-16 [D12.776.467.374.465.516]
        
        Interleukin-17 [D12.776.467.374.465.517]
        
        Interleukin-18 [D12.776.467.374.465.518]
        
        Interleukin-23 [D12.776.467.374.465.759]
        
        Interleukin-27 [D12.776.467.374.465.800]
        
        Interleukin-33 [D12.776.467.374.465.850]
        
        Interleukin-22 [D12.776.467.374.465.925]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]
  - Cytokines [D23.529.374]
    - Interleukins [D23.529.374.465]

Interleukin-4 Preferred

Concept UI: M0024266
Scope Note: A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
Terms: Interleukin-4 Preferred Term
Term UI T046986
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1990); B Cell Stimulatory Factor-1
Term UI T046980
Date03/23/1989
LexicalTag NON
ThesaurusID NLM (1990); B-Cell Growth Factor-1
Term UI T046990
Date02/21/1996
LexicalTag NON
ThesaurusID NLM (1997); B-Cell Growth Factor-I
Term UI T046993
Date02/21/1996
LexicalTag NON
ThesaurusID NLM (1997); B-Cell Proliferating Factor
Term UI T046983
Date05/10/1989
LexicalTag NON
ThesaurusID NLM (1990); B-Cell Stimulating Factor-1
Term UI T046991
Date05/10/1989
LexicalTag NON
ThesaurusID NLM (1990); B-Cell Stimulatory Factor 1
Term UI T046981
Date03/23/1989
LexicalTag NON
ThesaurusID NLM (1990); B-Cell Stimulatory Factor-1
Term UI T046982
Date03/23/1989
LexicalTag NON
ThesaurusID NLM (1990); BCGF-1
Term UI T046992
Date02/21/1996
LexicalTag ABB
ThesaurusID NLM (1997); Binetrakin
Term UI T429788
Date11/28/2000
LexicalTag NON
ThesaurusID USAN (19XX); BSF-1
Term UI T046984
Date03/23/1989
LexicalTag ABB
ThesaurusID NLM (1990); IL-4
Term UI T046985
Date05/25/1989
LexicalTag ABB
ThesaurusID NLM (1990); IL4
Term UI T046989
Date03/05/1991
LexicalTag ABB
ThesaurusID NLM (1992); Mast Cell Growth Factor-2
Term UI T046987
Date03/23/1989
LexicalTag NON
ThesaurusID NLM (1990); MCGF-2
Term UI T046988
Date03/23/1989
LexicalTag ABB
ThesaurusID NLM (1990)

Interleukin-4 MeSH Descriptor Data 2025