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Histocompatibility Antigens Class II MeSH Descriptor Data 2023


MeSH Heading
Histocompatibility Antigens Class II
Tree Number(s)
D12.776.395.550.509
D12.776.543.550.440
D23.050.301.500.400
D23.050.705.552.410
Unique ID
D000949
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000949
Annotation
human & animal; see also HLA ANTIGENS & specifics for human
Scope Note
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Entry Term(s)
Antigens, Immune Response
Class II Antigen
Class II Antigens
Class II Histocompatibility Antigen
Class II Histocompatibility Antigens
Class II MHC Proteins
Class II Major Histocompatibility Antigen
Class II Major Histocompatibility Antigens
Class II Major Histocompatibility Molecules
I-A Antigen
I-A-Antigen
IA Antigen
Ia Antigens
Ia-Like Antigen
Ia-Like Antigens
Immune Response Antigens
Immune-Associated Antigens
Immune-Response-Associated Antigens
MHC Class II Molecule
MHC Class II Molecules
MHC II Peptide
MHC II Peptides
MHC-II Molecules
Registry Number
0
Previous Indexing
HLA Antigens (1975-1980)
Histocompatibility Antigens (1973-1980)
Isoantigens (1973-1980)
See Also
Genes, MHC Class II
Public MeSH Note
1989; see ANTIGENS, IMMUNE RESPONSE 1981-88
History Note
1989 (1973); use ANTIGENS, IMMUNE RESPONSE 1981-88
Date Established
1981/01/01
Date of Entry
1980/05/13
Revision Date
2021/06/30
Histocompatibility Antigens Class II Preferred
Immune-Associated Antigens Broader
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