MeSH Browser

MeSH Heading: Histocompatibility Antigens Class II
Tree Number(s): D09.400.430.890.509; D12.776.395.550.509; D12.776.543.550.440; D23.050.301.500.400; D23.050.705.552.410
Unique ID: D000949
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000949
Annotation: human & animal; see also HLA ANTIGENS & specifics for human
Scope Note: Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Entry Term(s): Antigens, Immune Response; Class II Antigen; Class II Antigens; Class II Histocompatibility Antigen; Class II Histocompatibility Antigens; Class II MHC Proteins; Class II Major Histocompatibility Antigen; Class II Major Histocompatibility Antigens; Class II Major Histocompatibility Molecules; I-A Antigen; I-A-Antigen; IA Antigen; Ia Antigens; Ia-Like Antigen; Ia-Like Antigens; Immune Response Antigens; Immune-Associated Antigens; Immune-Response-Associated Antigens; MHC Class II Molecule; MHC Class II Molecules; MHC II Peptide; MHC II Peptides; MHC-II Molecules
Previous Indexing: Histocompatibility Antigens (1973-1980); HLA Antigens (1975-1980); Isoantigens (1973-1980)
See Also: Genes, MHC Class II
Public MeSH Note: 1989; see ANTIGENS, IMMUNE RESPONSE 1981-88
History Note: 1989 (1973); use ANTIGENS, IMMUNE RESPONSE 1981-88
Date Established: 1981/01/01
Date of Entry: 1980/05/13
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]
    - Membrane Glycoproteins [D09.400.430.890]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]

Biological Factors [D23]
- Antigens [D23.050]
  - Antigens, Surface [D23.050.301]
    - Histocompatibility Antigens [D23.050.301.500]

Biological Factors [D23]
- Antigens [D23.050]
  - Isoantigens [D23.050.705]
    - Histocompatibility Antigens [D23.050.705.552]

Histocompatibility Antigens Class II Preferred

Concept UI: M0001420
Scope Note: Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Terms: Histocompatibility Antigens Class II Preferred Term
Term UI T002852
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1981); Class II Major Histocompatibility Molecules
Term UI T000936560
Date11/24/2017
LexicalTag NON
ThesaurusID NLM (2019); MHC-II Molecules
Term UI T000936561
Date11/24/2017
LexicalTag ABX
ThesaurusID NLM (2019); MHC II Peptides
Term UI T000936562
Date11/24/2017
LexicalTag NON
ThesaurusID NLM (2019); Class II MHC Proteins
Term UI T000936563
Date11/24/2017
LexicalTag ABX
ThesaurusID NLM (2019); Ia-Like Antigens
Term UI T002853
Date06/25/1986
LexicalTag NON
ThesaurusID UNK (19XX); IA Antigen
Term UI T002854
Date02/21/1993
LexicalTag NON
ThesaurusID NLM (1994); Class II Histocompatibility Antigen
Term UI T001089286
Date09/30/2020
LexicalTag NON
ThesaurusID NLM (2022); Ia Antigens
Term UI T002855
Date05/13/1980
LexicalTag NON
ThesaurusID UNK (19XX); Class II Major Histocompatibility Antigen
Term UI T001089287
Date09/30/2020
LexicalTag NON
ThesaurusID NLM (2022); Ia-Like Antigen
Term UI T001089289
Date09/30/2020
LexicalTag NON
ThesaurusID NLM (2022); Antigens, Immune Response
Term UI T002856
Date06/07/1988
LexicalTag NON
ThesaurusID UNK (19XX); Immune Response Antigens
Term UI T002857
Date05/13/1980
LexicalTag NON
ThesaurusID UNK (19XX); Immune-Response-Associated Antigens
Term UI T002858
Date06/25/1986
LexicalTag NON
ThesaurusID UNK (19XX); Class II Major Histocompatibility Antigens
Term UI T002859
Date03/08/1991
LexicalTag NON
ThesaurusID NLM (1992); I-A-Antigen
Term UI T002860
Date02/21/1993
LexicalTag NON
ThesaurusID NLM (1994); I-A Antigen
Term UI T002861
Date02/20/1993
LexicalTag NON
ThesaurusID NLM (1994); MHC Class II Molecule
Term UI T001089290
Date09/30/2020
LexicalTag NON
ThesaurusID NLM (2022); MHC II Peptide
Term UI T001089292
Date09/30/2020
LexicalTag NON
ThesaurusID NLM (2022); Class II Antigen
Term UI T002849
Date05/09/1987
LexicalTag NON
ThesaurusID UNK (19XX); Class II Antigens
Term UI T002850
Date06/25/1986
LexicalTag NON
ThesaurusID UNK (19XX); MHC Class II Molecules
Term UI T000936559
Date11/24/2017
LexicalTag ABX
ThesaurusID NLM (2019); Class II Histocompatibility Antigens
Term UI T002851
Date10/08/1986
LexicalTag NON
ThesaurusID UNK (19XX)

Immune-Associated Antigens Broader

Histocompatibility Antigens Class II MeSH Descriptor Data 2025