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AC133 Antigen MeSH Descriptor Data 2022


MeSH Heading
AC133 Antigen
Tree Number(s)
D12.776.395.550.007
D12.776.543.550.023
Unique ID
D000071916
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071916
Scope Note
A member of the prominin family, AC133 Antigen is a 5-transmembrane antigen occurring as several isoforms produced by alternative splicing which are processed into mature forms. In humans, it is expressed as a subset of CD34 (bright) human hematopoietic stem cells and CD34 positive leukemias. Functionally, it is associated with roles in cell differentiation, proliferation, and apoptosis. Specifically, it regulates the organization of apical plasma membrane in epithelial cells, disk morphogenesis during early retinal development, MAPK and Akt signaling pathways, and in cholesterol metabolism.
Entry Term(s)
AC133-1 Antigen
AC133-2 Antigen
AC141 Antigen
CD133 Antigen
Fudenine
PROML1
Prominin
Prominin-1
Prominin-Like PROML1
Registry Number
0
See Also
Antigen-Antibody Reactions
Public MeSH Note
2017; AC133 ANTIGEN was indexed under GLYCOPROTEINS, PEPTIDES and ANTIGENS, CD 1998-2016
History Note
2017(1998)
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2017/05/24
AC133 Antigen Preferred
AC141 Antigen Narrower
AC133-2 Antigen Narrower
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