MeSH Browser

MeSH Heading: AC133 Antigen
Tree Number(s): D09.400.430.890.007; D12.776.395.550.007; D12.776.543.550.023
Unique ID: D000071916
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071916
Scope Note: A member of the prominin family, AC133 Antigen is a 5-transmembrane antigen occurring as several isoforms produced by alternative splicing which are processed into mature forms. In humans, it is expressed as a subset of CD34 (bright) human hematopoietic stem cells and CD34 positive leukemias. Functionally, it is associated with roles in cell differentiation, proliferation, and apoptosis. Specifically, it regulates the organization of apical plasma membrane in epithelial cells, disk morphogenesis during early retinal development, MAPK and Akt signaling pathways, and in cholesterol metabolism.
Entry Term(s): AC133-1 Antigen; AC133-2 Antigen; AC141 Antigen; CD133 Antigen; Fudenine; PROML1; Prominin; Prominin-1; Prominin-Like PROML1
See Also: Antigen-Antibody Reactions
Public MeSH Note: 2017; AC133 ANTIGEN was indexed under GLYCOPROTEINS, PEPTIDES and ANTIGENS, CD 1998-2016
History Note: 2017(1998)
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]
    - Membrane Glycoproteins [D09.400.430.890]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]

AC133 Antigen Preferred

Concept UI: M0288458
Scope Note: A member of the prominin family, AC133 Antigen is a 5-transmembrane antigen occurring as several isoforms produced by alternative splicing which are processed into mature forms. In humans, it is expressed as a subset of CD34 (bright) human hematopoietic stem cells and CD34 positive leukemias. Functionally, it is associated with roles in cell differentiation, proliferation, and apoptosis. Specifically, it regulates the organization of apical plasma membrane in epithelial cells, disk morphogenesis during early retinal development, MAPK and Akt signaling pathways, and in cholesterol metabolism.
Terms: AC133 Antigen Preferred Term
Term UI T000897421
Date03/21/2016
LexicalTag NON
ThesaurusID NLM (2017); AC133-1 Antigen
Term UI T000897426
Date03/21/2016
LexicalTag NON
ThesaurusID NLM (2017); CD133 Antigen
Term UI T000897427
Date03/21/2016
LexicalTag NON
ThesaurusID NLM (2017); Fudenine
Term UI T000897428
Date03/21/2016
LexicalTag NON
ThesaurusID NLM (2017); Prominin
Term UI T000897429
Date03/21/2016
LexicalTag NON
ThesaurusID NLM (2017); Prominin-1
Term UI T000897430
Date03/21/2016
LexicalTag NON
ThesaurusID NLM (2017); Prominin-Like PROML1
Term UI T000897431
Date03/21/2016
LexicalTag NON
ThesaurusID NLM (2017); PROML1
Term UI T408214
Date02/29/2000
LexicalTag NON
ThesaurusID NLM (2000)

AC141 Antigen Narrower

AC133-2 Antigen Narrower

AC133 Antigen MeSH Descriptor Data 2025