- Concept UI
- M0288458
- Registry Numbers
- 0
- Scope Note
- A member of the prominin family, AC133 Antigen is a 5-transmembrane antigen occurring as several isoforms produced by alternative splicing which are processed into mature forms. In humans, it is expressed as a subset of CD34 (bright) human hematopoietic stem cells and CD34 positive leukemias. Functionally, it is associated with roles in cell differentiation, proliferation, and apoptosis. Specifically, it regulates the organization of apical plasma membrane in epithelial cells, disk morphogenesis during early retinal development, MAPK and Akt signaling pathways, and in cholesterol metabolism.
- Terms
-
AC133 Antigen
Preferred Term
Term UI
T000897421
Date03/21/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
AC133-1 Antigen
Term UI
T000897426
Date03/21/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
CD133 Antigen
Term UI
T000897427
Date03/21/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
Fudenine
Term UI
T000897428
Date03/21/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
Prominin
Term UI
T000897429
Date03/21/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
Prominin-1
Term UI
T000897430
Date03/21/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
Prominin-Like PROML1
Term UI
T000897431
Date03/21/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
PROML1
Term UI
T408214
Date02/29/2000
LexicalTag
NON
ThesaurusID
NLM (2000)