MeSH Browser

MeSH Heading: Ectodysplasins
Tree Number(s): D12.644.276.374.750.186; D12.776.395.550.275; D12.776.467.374.750.186; D12.776.543.550.275; D23.529.374.750.186
Unique ID: D053331
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053331
Scope Note: Transmembrane proteins belonging to the tumor necrosis factor superfamily that play an essential role in the normal development of several ectodermally derived organs. Several isoforms of the ectodysplasins exist due to multiple ALTERNATIVE SPLICING of the MRNA for the protein. The isoforms ectodysplasin A1 and ectodysplasin A2 are considered biologically active and each bind distinct ECTODYSPLASIN RECEPTORS. Genetic mutations that result in loss of function of ectodysplasin result in ECTODERMAL DYSPLASIA 1, ANHIDROTIC.
Entry Term(s): Ectodysplasin; Ectodysplasin A, Isoform 1; Ectodysplasin A, Isoform 2; Ectodysplasin A1; Ectodysplasin A2; Ectodysplasin-A
Registry Number: 0
See Also: Ectodermal Dysplasia 1, Anhidrotic
Public MeSH Note: 2007; ECTODYSPLASINS was indexed under MEMBRANE PROTEINS & TUMOR NECROSIS FACTORS 1998-2006
History Note: 2007(1999)
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2015/06/22

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0284074
Registry Number: 0
Scope Note: Transmembrane proteins belonging to the tumor necrosis factor superfamily that play an essential role in the normal development of several ectodermally derived organs. Several isoforms of the ectodysplasins exist due to multiple ALTERNATIVE SPLICING of the MRNA for the protein. The isoforms ectodysplasin A1 and ectodysplasin A2 are considered biologically active and each bind distinct ECTODYSPLASIN RECEPTORS. Genetic mutations that result in loss of function of ectodysplasin result in ECTODERMAL DYSPLASIA 1, ANHIDROTIC.
Terms: Ectodysplasins Preferred Term
Term UI T661745
Date12/07/2005
LexicalTag NON
ThesaurusID NLM (2007); Ectodysplasin-A
Term UI T661891
Date12/09/2005
LexicalTag NON
ThesaurusID NLM (2007); Ectodysplasin
Term UI T314079
LexicalTag NON
ThesaurusID NLM (2007)

Ectodysplasins MeSH Descriptor Data 2023