MeSH Browser

MeSH Heading: Cytokine TWEAK
Tree Number(s): D12.644.276.374.750.155; D12.776.467.374.750.155; D23.529.374.750.155
Unique ID: D000074049
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074049
Scope Note: A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION.
Entry Term(s): Apo3 Ligand; TNF-Related Weak Inducer of Apoptosis; TWEAK Cytokine; Tumor Necrosis Factor Ligand Superfamily Member 12
Previous Indexing: Tumor Necrosis Factors (2006-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/02/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000625319
Scope Note: A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION.
Terms: Cytokine TWEAK Preferred Term
Term UI T000913796
Date01/06/2017
LexicalTag ACX
ThesaurusID NLM (2018); Tumor Necrosis Factor Ligand Superfamily Member 12
Term UI T000913792
Date01/06/2017
LexicalTag NON
ThesaurusID NLM (2018); TNF-Related Weak Inducer of Apoptosis
Term UI T000913793
Date01/06/2017
LexicalTag ABX
ThesaurusID NLM (2018); Apo3 Ligand
Term UI T000913794
Date01/06/2017
LexicalTag ABX
ThesaurusID NLM (2018); TWEAK Cytokine
Term UI T000915455
Date02/07/2017
LexicalTag ACX
ThesaurusID NLM (2018)

Cytokine TWEAK MeSH Descriptor Data 2025