MeSH Browser

MeSH Heading: TNF-Related Apoptosis-Inducing Ligand
Tree Number(s): D12.644.276.374.750.625; D12.776.467.374.750.625; D23.529.374.750.625
Unique ID: D053221
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053221
Scope Note: A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.
Entry Term(s): Apo-2 Ligand; Apo-2L Protein; CD253 Antigen; TNF Superfamily, Member 10; TRAIL Protein; Tumor Necrosis Factor Ligand Superfamily Member 10
Public MeSH Note: 2007; TNF-RELATED APOPTOSIS-INDUCING LIGAND was indexed under APOPTOSIS REGULATORY PROTEINS, TUMOR NECROSIS FACTOR-ALPHA and MEMBRANE GLYCOPROTEINS 1996-2006
History Note: 2007(2005)
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2017/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0256022
Scope Note: A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.
Terms: TNF-Related Apoptosis-Inducing Ligand Preferred Term
Term UI T286027
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2007); CD253 Antigen
Term UI T000887906
Date10/14/2015
LexicalTag NON
ThesaurusID NLM (2017); Apo-2 Ligand
Term UI T286023
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2007); TRAIL Protein
Term UI T286026
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2007); Apo-2L Protein
Term UI T660199
Date11/28/2005
LexicalTag ABX
ThesaurusID NLM (2007); TNF Superfamily, Member 10
Term UI T660222
Date11/28/2005
LexicalTag ACX
ThesaurusID NLM (2007); Tumor Necrosis Factor Ligand Superfamily Member 10
Term UI T661554
Date12/07/2005
LexicalTag NON
ThesaurusID NLM (2007)

TNF-Related Apoptosis-Inducing Ligand MeSH Descriptor Data 2025