MeSH Browser

MeSH Heading: Histocompatibility Antigens Class I
Tree Number(s): D09.400.430.890.489; D12.776.395.550.489; D12.776.543.550.439; D23.050.301.500.100; D23.050.705.552.100
Unique ID: D015395
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015395
Annotation: human & animal
Scope Note: Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Entry Term(s): Class I Antigen; Class I Antigens; Class I Histocompatibility Antigen; Class I Histocompatibility Antigens; Class I Human Antigens; Class I MHC Protein; Class I MHC Proteins; Class I Major Histocompatibility Antigen; Class I Major Histocompatibility Antigens; Class I Major Histocompatibility Molecules; Human Class I Antigens; MHC Class I Molecule; MHC Class I Molecules; MHC-I Molecules; MHC-I Peptide; MHC-I Peptides
Previous Indexing: Histocompatibility Antigens (1973-1988); HLA Antigens (1978-1988)
See Also: Genes, MHC Class I
Public MeSH Note: 89
History Note: 89
Date Established: 1988/01/01
Date of Entry: 1988/06/06
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]
    - Membrane Glycoproteins [D09.400.430.890]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]

Biological Factors [D23]
- Antigens [D23.050]
  - Antigens, Surface [D23.050.301]
    - Histocompatibility Antigens [D23.050.301.500]

Biological Factors [D23]
- Antigens [D23.050]
  - Isoantigens [D23.050.705]
    - Histocompatibility Antigens [D23.050.705.552]

Histocompatibility Antigens Class I Preferred

Concept UI: M0023721
Scope Note: Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Terms: Histocompatibility Antigens Class I Preferred Term
Term UI T045404
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1988); Class I Major Histocompatibility Antigens
Term UI T045402
Date06/06/1988
LexicalTag NON
ThesaurusID UNK (19XX); Class I Histocompatibility Antigens
Term UI T045403
Date06/06/1988
LexicalTag NON
ThesaurusID UNK (19XX); MHC Class I Molecules
Term UI T000936552
Date11/24/2017
LexicalTag ABX
ThesaurusID NLM (2019); Class I Major Histocompatibility Molecules
Term UI T000936553
Date11/24/2017
LexicalTag NON
ThesaurusID NLM (2019); MHC-I Molecules
Term UI T000936554
Date11/24/2017
LexicalTag NON
ThesaurusID NLM (2019); MHC-I Peptides
Term UI T000936555
Date11/24/2017
LexicalTag NON
ThesaurusID NLM (2019); Class I MHC Proteins
Term UI T000936556
Date11/24/2017
LexicalTag NON
ThesaurusID NLM (2019); Class I Antigen
Term UI T001010126
Date03/12/2020
LexicalTag NON
ThesaurusID NLM (2021); Class I Histocompatibility Antigen
Term UI T001010127
Date03/12/2020
LexicalTag NON
ThesaurusID NLM (2021); Class I MHC Protein
Term UI T001010128
Date03/12/2020
LexicalTag NON
ThesaurusID NLM (2021); Class I Major Histocompatibility Antigen
Term UI T001010129
Date03/12/2020
LexicalTag NON
ThesaurusID NLM (2021); MHC Class I Molecule
Term UI T001010130
Date03/12/2020
LexicalTag NON
ThesaurusID NLM (2021); Class I Antigens
Term UI T045401
Date06/06/1988
LexicalTag NON
ThesaurusID UNK (19XX); MHC-I Peptide
Term UI T001010131
Date03/12/2020
LexicalTag NON
ThesaurusID NLM (2021)

Human Class I Antigens Narrower

Histocompatibility Antigens Class I MeSH Descriptor Data 2025