HLA-C Antigens MeSH Descriptor Data 2025

MeSH Heading: HLA-C Antigens
Tree Number(s): D09.400.430.890.489.600; D12.776.395.550.489.600; D12.776.543.550.439.600; D23.050.301.500.100.600; D23.050.301.500.450.390; D23.050.705.552.100.600; D23.050.705.552.450.390
Unique ID: D015236
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015236
Scope Note: Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the C locus on chromosome 6. They have significantly lower immunogenicity than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient crossmatching. Their primary role is their high-risk association with certain disease manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma).
Entry Term(s): Antigens, HLA-C; HLA-C
Previous Indexing: HLA Antigens (1977-1988)
Public MeSH Note: 89
History Note: 89
Date Established: 1989/01/01
Date of Entry: 1988/05/14
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]
    - Membrane Glycoproteins [D09.400.430.890]
      - Histocompatibility Antigens Class I [D09.400.430.890.489]
        
        beta 2-Microglobulin [D09.400.430.890.489.100]
        
        Hemochromatosis Protein [D09.400.430.890.489.200]
        
        HLA-A Antigens [D09.400.430.890.489.400]
        
        HLA-B Antigens [D09.400.430.890.489.500]
        
        HLA-C Antigens [D09.400.430.890.489.600]
        
        HLA-G Antigens [D09.400.430.890.489.700]
        
        HLA-E Antigens [D09.400.430.890.489.850]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]
      - Histocompatibility Antigens Class I [D12.776.395.550.489]
        
        beta 2-Microglobulin [D12.776.395.550.489.100]
        
        Hemochromatosis Protein [D12.776.395.550.489.200]
        
        HLA-A Antigens [D12.776.395.550.489.400]
        
        HLA-B Antigens [D12.776.395.550.489.500]
        
        HLA-C Antigens [D12.776.395.550.489.600]
        
        HLA-G Antigens [D12.776.395.550.489.700]
        
        HLA-E Antigens [D12.776.395.550.489.850]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Histocompatibility Antigens Class I [D12.776.543.550.439]
        
        beta 2-Microglobulin [D12.776.543.550.439.100]
        
        Hemochromatosis Protein [D12.776.543.550.439.200]
        
        HLA-A Antigens [D12.776.543.550.439.400]
        
        HLA-B Antigens [D12.776.543.550.439.500]
        
        HLA-C Antigens [D12.776.543.550.439.600]
        
        HLA-G Antigens [D12.776.543.550.439.700]
        
        HLA-E Antigens [D12.776.543.550.439.850]

Biological Factors [D23]
- Antigens [D23.050]
  - Antigens, Surface [D23.050.301]
    - Histocompatibility Antigens [D23.050.301.500]
      - Histocompatibility Antigens Class I [D23.050.301.500.100]
        
        beta 2-Microglobulin [D23.050.301.500.100.175]
        
        H-2 Antigens [D23.050.301.500.100.350]
        
        Hemochromatosis Protein [D23.050.301.500.100.363]
        
        Histocompatibility Antigen H-2D [D23.050.301.500.100.375]
        
        HLA-A Antigens [D23.050.301.500.100.400]
        
        HLA-B Antigens [D23.050.301.500.100.500]
        
        HLA-C Antigens [D23.050.301.500.100.600]
        
        HLA-G Antigens [D23.050.301.500.100.700]
        
        HLA-E Antigens [D23.050.301.500.100.850]

Biological Factors [D23]
- Antigens [D23.050]
  - Antigens, Surface [D23.050.301]
    - Histocompatibility Antigens [D23.050.301.500]
      - HLA Antigens [D23.050.301.500.450]
        
        HLA-A Antigens [D23.050.301.500.450.370]
        
        HLA-B Antigens [D23.050.301.500.450.380]
        
        HLA-C Antigens [D23.050.301.500.450.390]
        
        HLA-D Antigens [D23.050.301.500.450.400]
        
        HLA-G Antigens [D23.050.301.500.450.700]

Biological Factors [D23]
- Antigens [D23.050]
  - Isoantigens [D23.050.705]
    - Histocompatibility Antigens [D23.050.705.552]
      - Histocompatibility Antigens Class I [D23.050.705.552.100]
        
        beta 2-Microglobulin [D23.050.705.552.100.175]
        
        H-2 Antigens [D23.050.705.552.100.350]
        
        Hemochromatosis Protein [D23.050.705.552.100.375]
        
        HLA-A Antigens [D23.050.705.552.100.400]
        
        HLA-B Antigens [D23.050.705.552.100.500]
        
        HLA-C Antigens [D23.050.705.552.100.600]
        
        HLA-G Antigens [D23.050.705.552.100.700]
        
        HLA-E Antigens [D23.050.705.552.100.850]

Biological Factors [D23]
- Antigens [D23.050]
  - Isoantigens [D23.050.705]
    - Histocompatibility Antigens [D23.050.705.552]
      - HLA Antigens [D23.050.705.552.450]
        
        HLA-A Antigens [D23.050.705.552.450.370]
        
        HLA-B Antigens [D23.050.705.552.450.380]
        
        HLA-C Antigens [D23.050.705.552.450.390]
        
        HLA-D Antigens [D23.050.705.552.450.400]
        
        HLA-G Antigens [D23.050.705.552.450.700]

HLA-C Antigens Preferred

Concept UI: M0023415
Scope Note: Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the C locus on chromosome 6. They have significantly lower immunogenicity than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient crossmatching. Their primary role is their high-risk association with certain disease manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma).
Terms: HLA-C Antigens Preferred Term
Term UI T044592
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1989); HLA-C
Term UI T044590
Date05/14/1988
LexicalTag ABB
ThesaurusID UNK (19XX); Antigens, HLA-C
Term UI T044591
Date05/14/1988
LexicalTag NON
ThesaurusID UNK (19XX)

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