HLA-B Antigens MeSH Descriptor Data 2025

MeSH Heading: HLA-B Antigens
Tree Number(s): D09.400.430.890.489.500; D12.776.395.550.489.500; D12.776.543.550.439.500; D23.050.301.500.100.500; D23.050.301.500.450.380; D23.050.705.552.100.500; D23.050.705.552.450.380
Unique ID: D015235
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015235
Annotation: general; prefer specifics
Scope Note: Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
Entry Term(s): Antigens, HLA-B; HLA-B; HLA-B Antigen
Previous Indexing: Histocompatibility Antigens (1975-1981); HLA Antigens (1975-1988)
Public MeSH Note: 89
History Note: 89
Date Established: 1989/01/01
Date of Entry: 1988/05/14
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]
    - Membrane Glycoproteins [D09.400.430.890]
      - Histocompatibility Antigens Class I [D09.400.430.890.489]
        
        beta 2-Microglobulin [D09.400.430.890.489.100]
        
        Hemochromatosis Protein [D09.400.430.890.489.200]
        
        HLA-A Antigens [D09.400.430.890.489.400]
        
        HLA-B Antigens [D09.400.430.890.489.500]
        
        HLA-B7 Antigen [D09.400.430.890.489.500.070]
        
        HLA-B8 Antigen [D09.400.430.890.489.500.080]
        
        HLA-B13 Antigen [D09.400.430.890.489.500.130]
        
        HLA-B14 Antigen [D09.400.430.890.489.500.140]
        
        HLA-B15 Antigen [D09.400.430.890.489.500.150]
        
        HLA-B18 Antigen [D09.400.430.890.489.500.180]
        
        HLA-B27 Antigen [D09.400.430.890.489.500.270]
        
        HLA-B35 Antigen [D09.400.430.890.489.500.350]
        
        HLA-B37 Antigen [D09.400.430.890.489.500.370]
        
        HLA-B38 Antigen [D09.400.430.890.489.500.380]
        
        HLA-B39 Antigen [D09.400.430.890.489.500.390]
        
        HLA-B40 Antigen [D09.400.430.890.489.500.400]
        
        HLA-B44 Antigen [D09.400.430.890.489.500.440]
        
        HLA-B51 Antigen [D09.400.430.890.489.500.510]
        
        HLA-B52 Antigen [D09.400.430.890.489.500.520]
        
        HLA-C Antigens [D09.400.430.890.489.600]
        
        HLA-G Antigens [D09.400.430.890.489.700]
        
        HLA-E Antigens [D09.400.430.890.489.850]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]
      - Histocompatibility Antigens Class I [D12.776.395.550.489]
        
        beta 2-Microglobulin [D12.776.395.550.489.100]
        
        Hemochromatosis Protein [D12.776.395.550.489.200]
        
        HLA-A Antigens [D12.776.395.550.489.400]
        
        HLA-B Antigens [D12.776.395.550.489.500]
        
        HLA-B7 Antigen [D12.776.395.550.489.500.070]
        
        HLA-B8 Antigen [D12.776.395.550.489.500.080]
        
        HLA-B13 Antigen [D12.776.395.550.489.500.130]
        
        HLA-B14 Antigen [D12.776.395.550.489.500.140]
        
        HLA-B15 Antigen [D12.776.395.550.489.500.150]
        
        HLA-B18 Antigen [D12.776.395.550.489.500.180]
        
        HLA-B27 Antigen [D12.776.395.550.489.500.270]
        
        HLA-B35 Antigen [D12.776.395.550.489.500.350]
        
        HLA-B37 Antigen [D12.776.395.550.489.500.370]
        
        HLA-B38 Antigen [D12.776.395.550.489.500.380]
        
        HLA-B39 Antigen [D12.776.395.550.489.500.390]
        
        HLA-B40 Antigen [D12.776.395.550.489.500.400]
        
        HLA-B44 Antigen [D12.776.395.550.489.500.440]
        
        HLA-B51 Antigen [D12.776.395.550.489.500.510]
        
        HLA-B52 Antigen [D12.776.395.550.489.500.520]
        
        HLA-C Antigens [D12.776.395.550.489.600]
        
        HLA-G Antigens [D12.776.395.550.489.700]
        
        HLA-E Antigens [D12.776.395.550.489.850]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Histocompatibility Antigens Class I [D12.776.543.550.439]
        
        beta 2-Microglobulin [D12.776.543.550.439.100]
        
        Hemochromatosis Protein [D12.776.543.550.439.200]
        
        HLA-A Antigens [D12.776.543.550.439.400]
        
        HLA-B Antigens [D12.776.543.550.439.500]
        
        HLA-B7 Antigen [D12.776.543.550.439.500.070]
        
        HLA-B8 Antigen [D12.776.543.550.439.500.080]
        
        HLA-B13 Antigen [D12.776.543.550.439.500.130]
        
        HLA-B14 Antigen [D12.776.543.550.439.500.140]
        
        HLA-B15 Antigen [D12.776.543.550.439.500.150]
        
        HLA-B18 Antigen [D12.776.543.550.439.500.180]
        
        HLA-B27 Antigen [D12.776.543.550.439.500.270]
        
        HLA-B35 Antigen [D12.776.543.550.439.500.350]
        
        HLA-B37 Antigen [D12.776.543.550.439.500.370]
        
        HLA-B38 Antigen [D12.776.543.550.439.500.380]
        
        HLA-B39 Antigen [D12.776.543.550.439.500.390]
        
        HLA-B40 Antigen [D12.776.543.550.439.500.400]
        
        HLA-B44 Antigen [D12.776.543.550.439.500.440]
        
        HLA-B51 Antigen [D12.776.543.550.439.500.510]
        
        HLA-B52 Antigen [D12.776.543.550.439.500.520]
        
        HLA-C Antigens [D12.776.543.550.439.600]
        
        HLA-G Antigens [D12.776.543.550.439.700]
        
        HLA-E Antigens [D12.776.543.550.439.850]

Biological Factors [D23]
- Antigens [D23.050]
  - Antigens, Surface [D23.050.301]
    - Histocompatibility Antigens [D23.050.301.500]
      - Histocompatibility Antigens Class I [D23.050.301.500.100]
        
        beta 2-Microglobulin [D23.050.301.500.100.175]
        
        H-2 Antigens [D23.050.301.500.100.350]
        
        Hemochromatosis Protein [D23.050.301.500.100.363]
        
        Histocompatibility Antigen H-2D [D23.050.301.500.100.375]
        
        HLA-A Antigens [D23.050.301.500.100.400]
        
        HLA-B Antigens [D23.050.301.500.100.500]
        
        HLA-B7 Antigen [D23.050.301.500.100.500.070]
        
        HLA-B8 Antigen [D23.050.301.500.100.500.080]
        
        HLA-B13 Antigen [D23.050.301.500.100.500.130]
        
        HLA-B14 Antigen [D23.050.301.500.100.500.140]
        
        HLA-B15 Antigen [D23.050.301.500.100.500.150]
        
        HLA-B18 Antigen [D23.050.301.500.100.500.180]
        
        HLA-B27 Antigen [D23.050.301.500.100.500.270]
        
        HLA-B35 Antigen [D23.050.301.500.100.500.350]
        
        HLA-B37 Antigen [D23.050.301.500.100.500.370]
        
        HLA-B38 Antigen [D23.050.301.500.100.500.380]
        
        HLA-B39 Antigen [D23.050.301.500.100.500.390]
        
        HLA-B40 Antigen [D23.050.301.500.100.500.400]
        
        HLA-B44 Antigen [D23.050.301.500.100.500.440]
        
        HLA-B51 Antigen [D23.050.301.500.100.500.510]
        
        HLA-B52 Antigen [D23.050.301.500.100.500.520]
        
        HLA-C Antigens [D23.050.301.500.100.600]
        
        HLA-G Antigens [D23.050.301.500.100.700]
        
        HLA-E Antigens [D23.050.301.500.100.850]

Biological Factors [D23]
- Antigens [D23.050]
  - Antigens, Surface [D23.050.301]
    - Histocompatibility Antigens [D23.050.301.500]
      - HLA Antigens [D23.050.301.500.450]
        
        HLA-A Antigens [D23.050.301.500.450.370]
        
        HLA-B Antigens [D23.050.301.500.450.380]
        
        HLA-B7 Antigen [D23.050.301.500.450.380.070]
        
        HLA-B8 Antigen [D23.050.301.500.450.380.080]
        
        HLA-B13 Antigen [D23.050.301.500.450.380.130]
        
        HLA-B14 Antigen [D23.050.301.500.450.380.140]
        
        HLA-B15 Antigen [D23.050.301.500.450.380.150]
        
        HLA-B18 Antigen [D23.050.301.500.450.380.180]
        
        HLA-B27 Antigen [D23.050.301.500.450.380.270]
        
        HLA-B35 Antigen [D23.050.301.500.450.380.350]
        
        HLA-B37 Antigen [D23.050.301.500.450.380.370]
        
        HLA-B38 Antigen [D23.050.301.500.450.380.380]
        
        HLA-B39 Antigen [D23.050.301.500.450.380.390]
        
        HLA-B40 Antigen [D23.050.301.500.450.380.400]
        
        HLA-B44 Antigen [D23.050.301.500.450.380.440]
        
        HLA-B51 Antigen [D23.050.301.500.450.380.510]
        
        HLA-B52 Antigen [D23.050.301.500.450.380.520]
        
        HLA-C Antigens [D23.050.301.500.450.390]
        
        HLA-D Antigens [D23.050.301.500.450.400]
        
        HLA-G Antigens [D23.050.301.500.450.700]

Biological Factors [D23]
- Antigens [D23.050]
  - Isoantigens [D23.050.705]
    - Histocompatibility Antigens [D23.050.705.552]
      - Histocompatibility Antigens Class I [D23.050.705.552.100]
        
        beta 2-Microglobulin [D23.050.705.552.100.175]
        
        H-2 Antigens [D23.050.705.552.100.350]
        
        Hemochromatosis Protein [D23.050.705.552.100.375]
        
        HLA-A Antigens [D23.050.705.552.100.400]
        
        HLA-B Antigens [D23.050.705.552.100.500]
        
        HLA-B7 Antigen [D23.050.705.552.100.500.070]
        
        HLA-B8 Antigen [D23.050.705.552.100.500.080]
        
        HLA-B13 Antigen [D23.050.705.552.100.500.130]
        
        HLA-B14 Antigen [D23.050.705.552.100.500.140]
        
        HLA-B15 Antigen [D23.050.705.552.100.500.150]
        
        HLA-B18 Antigen [D23.050.705.552.100.500.180]
        
        HLA-B27 Antigen [D23.050.705.552.100.500.270]
        
        HLA-B35 Antigen [D23.050.705.552.100.500.350]
        
        HLA-B37 Antigen [D23.050.705.552.100.500.370]
        
        HLA-B38 Antigen [D23.050.705.552.100.500.380]
        
        HLA-B39 Antigen [D23.050.705.552.100.500.390]
        
        HLA-B40 Antigen [D23.050.705.552.100.500.400]
        
        HLA-B44 Antigen [D23.050.705.552.100.500.440]
        
        HLA-B51 Antigen [D23.050.705.552.100.500.510]
        
        HLA-B52 Antigen [D23.050.705.552.100.500.520]
        
        HLA-C Antigens [D23.050.705.552.100.600]
        
        HLA-G Antigens [D23.050.705.552.100.700]
        
        HLA-E Antigens [D23.050.705.552.100.850]

Biological Factors [D23]
- Antigens [D23.050]
  - Isoantigens [D23.050.705]
    - Histocompatibility Antigens [D23.050.705.552]
      - HLA Antigens [D23.050.705.552.450]
        
        HLA-A Antigens [D23.050.705.552.450.370]
        
        HLA-B Antigens [D23.050.705.552.450.380]
        
        HLA-B7 Antigen [D23.050.705.552.450.380.070]
        
        HLA-B8 Antigen [D23.050.705.552.450.380.080]
        
        HLA-B13 Antigen [D23.050.705.552.450.380.130]
        
        HLA-B14 Antigen [D23.050.705.552.450.380.140]
        
        HLA-B15 Antigen [D23.050.705.552.450.380.150]
        
        HLA-B18 Antigen [D23.050.705.552.450.380.180]
        
        HLA-B27 Antigen [D23.050.705.552.450.380.270]
        
        HLA-B35 Antigen [D23.050.705.552.450.380.350]
        
        HLA-B37 Antigen [D23.050.705.552.450.380.370]
        
        HLA-B38 Antigen [D23.050.705.552.450.380.380]
        
        HLA-B39 Antigen [D23.050.705.552.450.380.390]
        
        HLA-B40 Antigen [D23.050.705.552.450.380.400]
        
        HLA-B44 Antigen [D23.050.705.552.450.380.440]
        
        HLA-B51 Antigen [D23.050.705.552.450.380.510]
        
        HLA-B52 Antigen [D23.050.705.552.450.380.520]
        
        HLA-C Antigens [D23.050.705.552.450.390]
        
        HLA-D Antigens [D23.050.705.552.450.400]
        
        HLA-G Antigens [D23.050.705.552.450.700]

HLA-B Antigens Preferred

Concept UI: M0023414
Scope Note: Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
Terms: HLA-B Antigens Preferred Term
Term UI T044589
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1989); HLA-B Antigen
Term UI T000998802
Date11/21/2019
LexicalTag NON
ThesaurusID NLM (2021); HLA-B
Term UI T044587
Date05/14/1988
LexicalTag ABB
ThesaurusID UNK (19XX); Antigens, HLA-B
Term UI T044588
Date05/14/1988
LexicalTag NON
ThesaurusID UNK (19XX)

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