MeSH Browser

MeSH Heading: Factor VIIIa
Tree Number(s): D12.776.124.125.350.300; D23.119.350.300
Unique ID: D015944
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015944
Scope Note: Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va.
Entry Term(s): Blood Coagulation Factor VIII, Activated; Coagulation Factor VIIIa; Factor 8A; Factor Eight A; Factor VIII, Activated; Factor VIII, Thrombin-Activated; Factor VIIIa Heavy Chain, 200 kDa Isoform; Factor VIIIa Heavy Chain, 92 kDa Isoform; Factor VIIIa Light Chain
CAS Type 1 Name: Blood-coagulation factor VIIIa, procoagulant
Previous Indexing: Factor VIII (1981-1989)
See Also: Coagulants
Public MeSH Note: 90
History Note: 90
Entry Combination: deficiency:Hemophilia A
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2019/05/30

Entry Combination: deficiency:Hemophilia A
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0024392
Scope Note: Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va.
Terms: Factor VIIIa Preferred Term
Term UI T047324
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1990); Factor Eight A
Term UI T000913548
Date01/04/2017
LexicalTag NON
ThesaurusID NLM (2018); Blood Coagulation Factor VIII, Activated
Term UI T047321
Date05/17/1989
LexicalTag NON
ThesaurusID NLM (1990); Factor 8A
Term UI T000913547
Date01/04/2017
LexicalTag NON
ThesaurusID NLM (2018); Factor VIII, Thrombin-Activated
Term UI T047323
Date04/21/1989
LexicalTag NON
ThesaurusID NLM (1990); Coagulation Factor VIIIa
Term UI T047325
Date07/31/1996
LexicalTag NON
ThesaurusID NLM (1998); Factor VIII, Activated
Term UI T047322
Date05/17/1989
LexicalTag NON
ThesaurusID NLM (1990)

Factor VIIIa MeSH Descriptor Data 2025