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Renin-Angiotensin System MeSH Descriptor Data 2023


MeSH Heading
Renin-Angiotensin System
Tree Number(s)
G03.820
G09.330.380.813
Unique ID
D012084
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D012084
Annotation
note entry term but do not index under ALDOSTERONE unless particularly discussed
Scope Note
A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.
Entry Version
RA SYSTEM
Entry Term(s)
Renin-Angiotensin-Aldosterone System
Previous Indexing
Angiotensin II (1966-1981)
Renin (1966-1981)
See Also
Angiotensin-Converting Enzyme Inhibitors
Kallikrein-Kinin System
Public MeSH Note
82
History Note
82
Date Established
1982/01/01
Date of Entry
1981/05/19
Revision Date
2016/07/01
Renin-Angiotensin System Preferred
Renin-Angiotensin-Aldosterone System Broader
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