MeSH Browser

MeSH Heading: Transforming Growth Factor beta
Tree Number(s): D12.644.276.374.687; D12.644.276.954.775; D12.776.467.374.687; D12.776.467.942.775; D23.529.374.687; D23.529.942.775
Unique ID: D016212
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016212
Scope Note: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
Entry Term(s): Bone-Derived Transforming Growth Factor; Milk Growth Factor; Platelet Transforming Growth Factor; TGF-beta; TGFbeta
NLM Classification #: QU 107
Previous Indexing: Peptides (1983-1988); Transforming Growth Factors (1989-1990)
Public MeSH Note: 91; was see TRANSFORMING GROWTH FACTORS 1989-90; TGF-BETA was see TRANSFORMING GROWTH FACTORS 1989-90
Online Note: use TRANSFORMING GROWTH FACTORS to search TRANSFORMING GROWTH FACTOR BETA & TGF-BETA 1989-90
History Note: 91; was see TRANSFORMING GROWTH FACTORS 1989-90; TGF-BETA was see TRANSFORMING GROWTH FACTORS 1989-90
Date Established: 1991/01/01
Date of Entry: 1990/06/29
Revision Date: 2015/06/02

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]
    - Cytokines [D12.644.276.374]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]
    - TGF-beta Superfamily Proteins [D12.644.276.954]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - Cytokines [D12.776.467.374]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - TGF-beta Superfamily Proteins [D12.776.467.942]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]
  - Cytokines [D23.529.374]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]
  - TGF-beta Superfamily Proteins [D23.529.942]

Transforming Growth Factor beta Preferred

Concept UI: M0024757
Scope Note: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
Terms: Transforming Growth Factor beta Preferred Term
Term UI T048240
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1991); Platelet Transforming Growth Factor
Term UI T048239
Date02/27/1990
LexicalTag NON
ThesaurusID NLM (1991); Bone-Derived Transforming Growth Factor
Term UI T048241
Date02/27/1990
LexicalTag NON
ThesaurusID NLM (1991); TGF-beta
Term UI T048242
Date02/27/1990
LexicalTag ABB
ThesaurusID NLM (1991); TGFbeta
Term UI T048243
Date02/27/1990
LexicalTag ABB
ThesaurusID NLM (1991); Milk Growth Factor
Term UI T217778
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2001)

Transforming Growth Factor beta MeSH Descriptor Data 2025