MeSH Browser

MeSH Heading: Transforming Growth Factor beta1
Tree Number(s): D12.644.276.374.687.100; D12.644.276.954.775.100; D12.776.467.374.687.100; D12.776.467.942.775.100; D23.529.374.687.100; D23.529.942.775.100
Unique ID: D053773
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053773
Scope Note: A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.
Entry Term(s): TGF-beta-1; TGF-beta1; TGF-beta1 Latency-Associated Protein; TGF-beta1LAP; Transforming Growth Factor beta 1 Latency Associated Peptide; Transforming Growth Factor beta I; Transforming Growth Factor-beta1
Public MeSH Note: 2007; TRANSFORMING GROWTH FACTOR BETA1 was indexed under TRANSFORMING GROWTH FACTOR 2000-2006; TRANSFORMING GROWTH FACTOR BETA 1 LATENCY ASSOCIATED PEPTIDE was indexed under TRANSFORMING GROWTH FACTOR 1992-2006; TRANSFORMING GROWTH FACTOR BETA I was indexed under PROTEINS 2005-2006
History Note: 2007(1992)
Entry Combination: deficiency:Camurati-Engelmann Syndrome
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2020/02/21

Entry Combination: deficiency:Camurati-Engelmann Syndrome
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0024760
Scope Note: A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.
Terms: Transforming Growth Factor beta1 Preferred Term
Term UI T410572
Date03/29/2000
LexicalTag NON
ThesaurusID NLM (2007); Transforming Growth Factor-beta1
Term UI T000997981
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); TGF-beta-1
Term UI T048253
Date01/16/1991
LexicalTag NON
ThesaurusID NLM (2007); TGF-beta1
Term UI T048252
Date02/27/1990
LexicalTag ABB
ThesaurusID NLM (2007); Transforming Growth Factor beta I
Term UI T642063
Date06/03/2005
LexicalTag NON
ThesaurusID NLM (2007)

Transforming Growth Factor beta1 MeSH Descriptor Data 2025