MeSH Browser

MeSH Heading: Rho Guanine Nucleotide Exchange Factors
Tree Number(s): D12.644.360.325.300.099; D12.776.476.325.300.099
Unique ID: D064067
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D064067
Scope Note: Signaling proteins which function as master molecular switches by activating Rho GTPases through conversion of guanine nucleotides. Rho GTPases in turn control many aspects of cell behavior through the regulation of multiple downstream signal transduction pathways.
Entry Term(s): ARHGEF1; Cool-1 Protein; PAK-Interacting Exchange Factor beta; Rho Guanine Nucleotide Exchange Factor (GEF) 1; Rho Guanine Nucleotide Exchange Factor 6; Rho Guanine Nucleotide Exchange Factor 7; Rho Guanine Nucleotide Exchange Factor p115; RhoGEF; beta PIX Protein; betaPIX Protein; p115 RhoGEF; p115RhoGEF
Registry Numbers: 0
Public MeSH Note: 2014; was indexed under GUANINE NUCLEOTIDE EXCHANGE FACTORS
History Note: 2014
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Revision Date: 2015/11/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0065423
Registry Numbers: 0
Terms: Rho Guanine Nucleotide Exchange Factor p115 Preferred Term
Term UI T835410
Date01/09/2013
LexicalTag ABX
ThesaurusID NLM (2014); p115RhoGEF
Term UI T095448
Date01/01/1955
LexicalTag LAB
ThesaurusID NLM (1999); ARHGEF1
Term UI T586510
Date05/13/2004
LexicalTag ABB
ThesaurusID NLM (2004); p115 RhoGEF
Term UI T835411
Date01/09/2013
LexicalTag LAB
ThesaurusID NLM (2014); Rho Guanine Nucleotide Exchange Factor (GEF) 1
Term UI T835412
Date01/09/2013
LexicalTag ABX
ThesaurusID NLM (2014); RhoGEF
Term UI T835414
Date01/09/2013
LexicalTag ABB
ThesaurusID NLM (2014)

Concept UI: M0298631
Registry Numbers: 0
Terms: Rho Guanine Nucleotide Exchange Factor 7 Preferred Term
Term UI T835401
Date01/09/2013
LexicalTag ABX
ThesaurusID NLM (2014); beta PIX Protein
Term UI T835402
Date01/09/2013
LexicalTag NON
ThesaurusID NLM (2014); betaPIX Protein
Term UI T835403
Date01/09/2013
LexicalTag NON
ThesaurusID NLM (2014); Cool-1 Protein
Term UI T835406
Date01/09/2013
LexicalTag NON
ThesaurusID NLM (2014); PAK-Interacting Exchange Factor beta
Term UI T835407
Date01/09/2013
LexicalTag ABX
ThesaurusID NLM (2014)

Rho Guanine Nucleotide Exchange Factors MeSH Descriptor Data 2025