MeSH Browser

MeSH Heading: Etanercept
Tree Number(s): D12.644.541.500.697.624; D12.776.124.486.485.538.500.624; D12.776.124.486.485.680.697.624; D12.776.124.790.651.538.500.624; D12.776.124.790.651.680.660.624; D12.776.377.715.548.538.500.624; D12.776.377.715.548.680.660.624; D12.776.543.750.705.852.760.232
Unique ID: D000068800
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000068800
Scope Note: A recombinant version of soluble human TNF receptor fused to an IgG FC fragment that binds specifically to TUMOR NECROSIS FACTOR and inhibits its binding with endogenous TNF receptors. It prevents the inflammatory effect of TNF and is used to treat RHEUMATOID ARTHRITIS; PSORIATIC ARTHRITIS and ANKYLOSING SPONDYLITIS.
Entry Term(s): Enbrel; Erelzi; Etanercept-szzs; Recombinant Human Dimeric TNF Receptor Type II-IgG Fusion Protein; TNF Receptor Type II-IgG Fusion Protein; TNFR-Fc Fusion Protein; TNR 001; TNR-001; TNT Receptor Fusion Protein; TNTR-Fc
Pharm Action: Anti-Inflammatory Agents, Non-Steroidal
Gastrointestinal Agents
Immunosuppressive Agents
Antirheumatic Agents
Related Numbers: 185243-69-0
Public MeSH Note: 2016; ETANERCEPT was indexed under IMMUNOGLOBULIN G and RECEPTORS, TUMOR NECROSIS FACTOR 1997-2015
History Note: 2016 (1997)
Date Established: 2016/01/01
Date of Entry: 2015/07/09
Revision Date: 2017/12/14

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analogs & derivatives (AA)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Peptide Fragments [D12.644.541]
    - Immunoglobulin Fragments [D12.644.541.500]
      - Immunoglobulin Fc Fragments [D12.644.541.500.697]
        
        CD4 Immunoadhesins [D12.644.541.500.697.249]
        
        Etanercept [D12.644.541.500.697.624]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Immunoproteins [D12.776.124.486]
      - Immunoglobulins [D12.776.124.486.485]
        
        Immunoglobulin Constant Regions [D12.776.124.486.485.538]
        
        Immunoglobulin Fc Fragments [D12.776.124.486.485.538.500]
        
        CD4 Immunoadhesins [D12.776.124.486.485.538.500.249]
        
        Etanercept [D12.776.124.486.485.538.500.624]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Immunoproteins [D12.776.124.486]
      - Immunoglobulins [D12.776.124.486.485]
        
        Immunoglobulin Fragments [D12.776.124.486.485.680]
        
        Immunoglobulin Fc Fragments [D12.776.124.486.485.680.697]
        
        CD4 Immunoadhesins [D12.776.124.486.485.680.697.249]
        
        Etanercept [D12.776.124.486.485.680.697.624]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Serum Globulins [D12.776.124.790]
      - Immunoglobulins [D12.776.124.790.651]
        
        Immunoglobulin Constant Regions [D12.776.124.790.651.538]
        
        Immunoglobulin Fc Fragments [D12.776.124.790.651.538.500]
        
        CD4 Immunoadhesins [D12.776.124.790.651.538.500.249]
        
        Etanercept [D12.776.124.790.651.538.500.624]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Serum Globulins [D12.776.124.790]
      - Immunoglobulins [D12.776.124.790.651]
        
        Immunoglobulin Fragments [D12.776.124.790.651.680]
        
        Immunoglobulin Fc Fragments [D12.776.124.790.651.680.660]
        
        CD4 Immunoadhesins [D12.776.124.790.651.680.660.249]
        
        Etanercept [D12.776.124.790.651.680.660.624]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Globulins [D12.776.377]
    - Serum Globulins [D12.776.377.715]
      - Immunoglobulins [D12.776.377.715.548]
        
        Immunoglobulin Constant Regions [D12.776.377.715.548.538]
        
        Immunoglobulin Fc Fragments [D12.776.377.715.548.538.500]
        
        CD4 Immunoadhesins [D12.776.377.715.548.538.500.249]
        
        Etanercept [D12.776.377.715.548.538.500.624]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Globulins [D12.776.377]
    - Serum Globulins [D12.776.377.715]
      - Immunoglobulins [D12.776.377.715.548]
        
        Immunoglobulin Fragments [D12.776.377.715.548.680]
        
        Immunoglobulin Fc Fragments [D12.776.377.715.548.680.660]
        
        CD4 Immunoadhesins [D12.776.377.715.548.680.660.249]
        
        Etanercept [D12.776.377.715.548.680.660.624]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Receptors, Cytokine [D12.776.543.750.705.852]
        
        Receptors, Tumor Necrosis Factor [D12.776.543.750.705.852.760]
        
        Tumor Necrosis Factor Receptor Superfamily, Member 7 [D12.776.543.750.705.852.760.048]
        
        Ki-1 Antigen [D12.776.543.750.705.852.760.072]
        
        CD40 Antigens [D12.776.543.750.705.852.760.097]
        
        fas Receptor [D12.776.543.750.705.852.760.195]
        
        Tumor Necrosis Factor Receptor Superfamily, Member 9 [D12.776.543.750.705.852.760.220]
        
        B-Cell Activation Factor Receptor [D12.776.543.750.705.852.760.222]
        
        B-Cell Maturation Antigen [D12.776.543.750.705.852.760.226]
        
        Etanercept [D12.776.543.750.705.852.760.232]
        
        Glucocorticoid-Induced TNFR-Related Protein [D12.776.543.750.705.852.760.238]
        
        Lymphotoxin beta Receptor [D12.776.543.750.705.852.760.245]
        
        Receptor Activator of Nuclear Factor-kappa B [D12.776.543.750.705.852.760.345]
        
        Receptors, Ectodysplasin [D12.776.543.750.705.852.760.347]
        
        Receptors, OX40 [D12.776.543.750.705.852.760.350]
        
        Receptors, TNF-Related Apoptosis-Inducing Ligand [D12.776.543.750.705.852.760.396]
        
        Receptors, Tumor Necrosis Factor, Member 14 [D12.776.543.750.705.852.760.500]
        
        Receptors, Tumor Necrosis Factor, Member 25 [D12.776.543.750.705.852.760.505]
        
        Receptors, Tumor Necrosis Factor, Type I [D12.776.543.750.705.852.760.597]
        
        Receptors, Tumor Necrosis Factor, Type II [D12.776.543.750.705.852.760.798]
        
        Transmembrane Activator and CAML Interactor Protein [D12.776.543.750.705.852.760.899]
        
        Tumor Necrosis Factor Decoy Receptors [D12.776.543.750.705.852.760.949]
        
        TWEAK Receptor [D12.776.543.750.705.852.760.974]

Etanercept Preferred

TNF Receptor Type II-IgG Fusion Protein Narrower

Enbrel Narrower

TNFR-Fc Fusion Protein Narrower

Concept UI: M0276738
Terms: TNFR-Fc Fusion Protein Preferred Term
Term UI T000877315
Date03/24/2015
LexicalTag ABX
ThesaurusID NLM (1997); TNTR-Fc
Term UI T403898
Date12/28/1999
LexicalTag ABB
ThesaurusID NLM (1999); TNR 001
Term UI T403899
Date12/28/1999
LexicalTag LAB
ThesaurusID NLM (1999); TNR-001
Term UI T403900
Date12/28/1999
LexicalTag LAB
ThesaurusID NLM (1999); TNT Receptor Fusion Protein
Term UI T000877313
Date03/24/2015
LexicalTag ABX
ThesaurusID NLM (1999)

Erelzi Narrower

Etanercept-szzs Narrower

Recombinant Human Dimeric TNF Receptor Type II-IgG Fusion Protein Narrower

Etanercept MeSH Descriptor Data 2025