MeSH Browser

MeSH Heading: CD40 Antigens
Tree Number(s): D12.776.465.750; D12.776.543.750.705.852.760.097; D23.050.301.264.051.140; D23.101.100.150.140
Unique ID: D019013
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019013
Scope Note: Members of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. They are found on mature B-LYMPHOCYTES, some EPITHELIAL CELLS; and lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations in the CD40 antigen gene result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Entry Term(s): Antigens, CD40; CD40 Antigen; CDw40 Antigen; TNFRSF5 Receptor; Tumor Necrosis Factor Receptor Superfamily, Member 5
Previous Indexing: Antigens, CD (1990-1995); Antigens, Differentiation, B-Lymphocyte (1988-1995)
See Also: CD40 Ligand
Public MeSH Note: 2018; see ANTIGENS, CD40 1996-2017, CD40 ANTIGEN 1989-95, and CDW40 ANTIGEN 1988-95; CD40 ANTIGEN was indexed under ANTIGENS, CD 1990-95; and under ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE 1989-95; CDW40 ANTIGEN was indexed under ANTIGENS, CD 1990-95; and under ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE 1988-95
History Note: 2018 (1988)
Date Established: 1996/01/01
Date of Entry: 1995/05/26
Revision Date: 2020/03/27

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Immune Checkpoint Proteins [D12.776.465]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Receptors, Cytokine [D12.776.543.750.705.852]
        
        Receptors, Tumor Necrosis Factor [D12.776.543.750.705.852.760]
        
        Tumor Necrosis Factor Receptor Superfamily, Member 7 [D12.776.543.750.705.852.760.048]
        
        Ki-1 Antigen [D12.776.543.750.705.852.760.072]
        
        CD40 Antigens [D12.776.543.750.705.852.760.097]
        
        fas Receptor [D12.776.543.750.705.852.760.195]
        
        Tumor Necrosis Factor Receptor Superfamily, Member 9 [D12.776.543.750.705.852.760.220]
        
        B-Cell Activation Factor Receptor [D12.776.543.750.705.852.760.222]
        
        B-Cell Maturation Antigen [D12.776.543.750.705.852.760.226]
        
        Etanercept [D12.776.543.750.705.852.760.232]
        
        Glucocorticoid-Induced TNFR-Related Protein [D12.776.543.750.705.852.760.238]
        
        Lymphotoxin beta Receptor [D12.776.543.750.705.852.760.245]
        
        Receptor Activator of Nuclear Factor-kappa B [D12.776.543.750.705.852.760.345]
        
        Receptors, Ectodysplasin [D12.776.543.750.705.852.760.347]
        
        Receptors, OX40 [D12.776.543.750.705.852.760.350]
        
        Receptors, TNF-Related Apoptosis-Inducing Ligand [D12.776.543.750.705.852.760.396]
        
        Receptors, Tumor Necrosis Factor, Member 14 [D12.776.543.750.705.852.760.500]
        
        Receptors, Tumor Necrosis Factor, Member 25 [D12.776.543.750.705.852.760.505]
        
        Receptors, Tumor Necrosis Factor, Type I [D12.776.543.750.705.852.760.597]
        
        Receptors, Tumor Necrosis Factor, Type II [D12.776.543.750.705.852.760.798]
        
        Transmembrane Activator and CAML Interactor Protein [D12.776.543.750.705.852.760.899]
        
        Tumor Necrosis Factor Decoy Receptors [D12.776.543.750.705.852.760.949]
        
        TWEAK Receptor [D12.776.543.750.705.852.760.974]

Biological Factors [D23]
- Antigens [D23.050]
  - Antigens, Surface [D23.050.301]
    - Antigens, Differentiation [D23.050.301.264]
      - Antigens, Differentiation, B-Lymphocyte [D23.050.301.264.051]
        
        CD5 Antigens [D23.050.301.264.051.101]
        
        Antigens, CD19 [D23.050.301.264.051.119]
        
        Antigens, CD20 [D23.050.301.264.051.120]
        
        CD40 Antigens [D23.050.301.264.051.140]

Biological Factors [D23]
- Biomarkers [D23.101]
  - Antigens, Differentiation [D23.101.100]
    - Antigens, Differentiation, B-Lymphocyte [D23.101.100.150]

CD40 Antigens Preferred

Concept UI: M0028391
Scope Note: Members of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. They are found on mature B-LYMPHOCYTES, some EPITHELIAL CELLS; and lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations in the CD40 antigen gene result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Terms: CD40 Antigens Preferred Term
Term UI T056734
Date01/06/1995
LexicalTag NON
ThesaurusID NLM (1996); Tumor Necrosis Factor Receptor Superfamily, Member 5
Term UI T571726
Date02/06/2004
LexicalTag NON
ThesaurusID NLM (2005); TNFRSF5 Receptor
Term UI T572165
Date02/10/2004
LexicalTag ACX
ThesaurusID NLM (2005); CD40 Antigen
Term UI T056733
Date01/06/1995
LexicalTag NON
ThesaurusID NLM (1996); Antigens, CD40
Term UI T056735
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1996); CDw40 Antigen
Term UI T056736
Date01/06/1995
LexicalTag NON
ThesaurusID NLM (1996)

CD40 Antigens MeSH Descriptor Data 2025