NLM Logo

CD40 Antigens MeSH Descriptor Data 2023


MeSH Heading
CD40 Antigens
Tree Number(s)
D12.776.465.750
D12.776.543.750.705.852.760.097
D23.050.301.264.051.140
D23.101.100.150.140
Unique ID
D019013
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019013
Scope Note
Members of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. They are found on mature B-LYMPHOCYTES, some EPITHELIAL CELLS; and lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations in the CD40 antigen gene result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Entry Term(s)
Antigens, CD40
CD40 Antigen
CDw40 Antigen
TNFRSF5 Receptor
Tumor Necrosis Factor Receptor Superfamily, Member 5
Registry Number
0
Previous Indexing
Antigens, CD (1990-1995)
Antigens, Differentiation, B-Lymphocyte (1988-1995)
See Also
CD40 Ligand
Public MeSH Note
2018; see ANTIGENS, CD40 1996-2017, CD40 ANTIGEN 1989-95, and CDW40 ANTIGEN 1988-95; CD40 ANTIGEN was indexed under ANTIGENS, CD 1990-95; and under ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE 1989-95; CDW40 ANTIGEN was indexed under ANTIGENS, CD 1990-95; and under ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE 1988-95
History Note
2018 (1988)
Date Established
1996/01/01
Date of Entry
1995/05/26
Revision Date
2020/03/27
CD40 Antigens Preferred
page delivered in 0.17s