MeSH Browser

MeSH Heading: Immune Checkpoint Proteins
Tree Number(s): D12.776.465; D23.383
Unique ID: D000082102
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000082102
Scope Note: Immunomodulators that regulate immune system either in stimulatory or inhibitory fashion allowing IMMUNE TOLERANCE. Activation of suppressed immune system (IMMUNOSUPPRESSION (PHYSIOLOGY)) in immunotherapy by IMMUNE CHECKPOINT INHIBITORS often targets inhibitory checkpoint molecules.
Entry Term(s): Immune Checkpoint Molecule; Immune Checkpoint Molecules; Immune Checkpoint Protein; Inhibitory Checkpoint Molecule; Inhibitory Checkpoint Molecules; Stimulatory Checkpoint Molecule; Stimulatory Checkpoint Molecules
Public MeSH Note: 2021
History Note: 2021
Entry Combination: antagonists & inhibitors:Immune Checkpoint Inhibitors
Date Established: 2021/01/01
Date of Entry: 2020/07/07
Revision Date: 2020/05/27

Entry Combination: antagonists & inhibitors:Immune Checkpoint Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000675777
Scope Note: Immunomodulators that regulate immune system either in stimulatory or inhibitory fashion allowing IMMUNE TOLERANCE. Activation of suppressed immune system (IMMUNOSUPPRESSION (PHYSIOLOGY)) in immunotherapy by IMMUNE CHECKPOINT INHIBITORS often targets inhibitory checkpoint molecules.
Terms: Immune Checkpoint Proteins Preferred Term
Term UI T000994326
Date10/16/2019
LexicalTag NON
ThesaurusID NLM (2021); Immune Checkpoint Molecule
Term UI T000997298
Date11/18/2019
LexicalTag NON
ThesaurusID NLM (2021); Immune Checkpoint Molecules
Term UI T000994317
Date10/16/2019
LexicalTag NON
ThesaurusID NLM (2021); Immune Checkpoint Protein
Term UI T000997299
Date11/18/2019
LexicalTag NON
ThesaurusID NLM (2021)

Immune Checkpoint Proteins MeSH Descriptor Data 2025