MeSH Browser

MeSH Heading: Cystatins
Tree Number(s): D12.776.215
Unique ID: D015891
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015891
Annotation: general or unspecified; prefer specifics
Scope Note: A homologous group of endogenous CYSTEINE PROTEINASE INHIBITORS. The cystatins inhibit most CYSTEINE ENDOPEPTIDASES such as PAPAIN, and other peptidases which have a sulfhydryl group at the active site.
Entry Term(s): Cystatin; Cystatin Superfamily; Cystatin-Related Proteins; Stefin; Stefins; Type 1 Cystatins; Type 2 Cystatins; Type 3 Cystatins; Type I Cystatins; Type II Cystatins; Type III Cystatins
Pharm Action: Cysteine Proteinase Inhibitors
Registry Number: 0
Previous Indexing: Enzyme Inhibitors (1975-1978); Protease Inhibitors (1979-1989)
Public MeSH Note: 90
History Note: 90
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0516521
Registry Number: 0
Scope Note: Cystatins that occur primarily as intracellular proteins.
Terms: Type 1 Cystatins Preferred Term
Term UI T711159
Date12/14/2007
LexicalTag NON
ThesaurusID NLM (2009); Type I Cystatins
Term UI T711160
Date12/14/2007
LexicalTag NON
ThesaurusID NLM (2009); Stefins
Term UI T711161
Date12/14/2007
LexicalTag NON
ThesaurusID NLM (2009); Stefin
Term UI T001005745
Date01/17/2020
LexicalTag NON
ThesaurusID NLM (2021)

Cystatins MeSH Descriptor Data 2023