MeSH Browser

MeSH Heading: Aprotinin
Tree Number(s): D12.776.083
Unique ID: D007611
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007611
Scope Note: A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
Entry Term(s): Antilysin; BPTI, Basic Pancreatic Trypsin Inhibitor; Basic Pancreatic Trypsin Inhibitor; Bovine Kunitz Pancreatic Trypsin Inhibitor; Bovine Pancreatic Trypsin Inhibitor; Contrical; Contrykal; Dilmintal; Iniprol; Kallikrein-Trypsin Inactivator; Kontrikal; Kontrykal; Kunitz Pancreatic Trypsin Inhibitor; Pulmin; Traskolan; Trasylol; Trypsin Inhibitor, Basic, Pancreatic; Trypsin Inhibitor, Kunitz, Pancreatic; Zymofren
Pharm Action: Hemostatics
Trypsin Inhibitors
Serine Proteinase Inhibitors
Related Numbers: 9004-04-0
NLM Classification #: QU 143
Public MeSH Note: 90; was KALLIKREIN-TRYPSIN INACTIVATOR 1966-89
Online Note: use APROTININ to search KALLIKREIN-TRYPSIN INACTIVATOR 1966-89
History Note: 90; was KALLIKREIN-TRYPSIN INACTIVATOR 1966-89
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]

Aprotinin Preferred

Concept UI: M0011905
Related Numbers: 9004-04-0
Scope Note: A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
Terms: Aprotinin Preferred Term
Term UI T022861
Date01/01/1999
LexicalTag NON
ThesaurusID; Trypsin Inhibitor, Basic, Pancreatic
Term UI T022863
Date03/06/1996
LexicalTag NON
ThesaurusID NLM (1997); Bovine Kunitz Pancreatic Trypsin Inhibitor
Term UI T022864
Date04/01/1977
LexicalTag EPO
ThesaurusID UNK (19XX); Bovine Pancreatic Trypsin Inhibitor
Term UI T022865
Date08/01/1980
LexicalTag NON
ThesaurusID UNK (19XX); Basic Pancreatic Trypsin Inhibitor
Term UI T022862
Date04/01/1977
LexicalTag NON
ThesaurusID UNK (19XX); Kunitz Pancreatic Trypsin Inhibitor
Term UI T022867
Date04/01/1977
LexicalTag EPO
ThesaurusID UNK (19XX); Trypsin Inhibitor, Kunitz, Pancreatic
Term UI T022868
Date04/01/1977
LexicalTag EPO
ThesaurusID UNK (19XX); BPTI, Basic Pancreatic Trypsin Inhibitor
Term UI T022869
Date02/01/1996
LexicalTag NON
ThesaurusID NLM (1997); Kallikrein-Trypsin Inactivator
Term UI T022866
Date05/12/1989
LexicalTag NON
ThesaurusID NLM (1990)

Trasylol Related

Antilysin Narrower

Contrykal Narrower

Dilmintal Narrower

Iniprol Narrower

Pulmin Narrower

Traskolan Narrower

Zymofren Narrower

Aprotinin MeSH Descriptor Data 2025