MeSH Browser

MeSH Heading: CTLA-4 Antigen
Tree Number(s): D12.776.465.782; D12.776.543.750.705.222.750; D23.050.301.264.894.158; D23.101.100.894.158
Unique ID: D060908
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D060908
Scope Note: An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative regulator of peripheral T cell function. CTLA-4 antigen is believed to play role in inducing PERIPHERAL TOLERANCE.
Entry Term(s): Antigens, CD152; CD152 Antigen; CTLA-4 Protein; Cytotoxic T-Lymphocyte Antigen 4; Cytotoxic T-Lymphocyte-Associated Antigen 4
Registry Numbers: 0
See Also: Abatacept; Ipilimumab
Public MeSH Note: 2012; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4 was indexed under ANTIGENS, CD 2008-2011, and under ANTIGENS, DIFFERENTIATION 1992-2007
History Note: 2012(1991)
Date Established: 2012/01/01
Date of Entry: 2011/06/24
Revision Date: 2020/03/27

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Concept UI: M0555800
Registry Numbers: 0
Scope Note: An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative regulator of peripheral T cell function. CTLA-4 antigen is believed to play role in inducing PERIPHERAL TOLERANCE.
Terms: CTLA-4 Antigen Preferred Term
Term UI T787436
Date03/21/2011
LexicalTag ABX
ThesaurusID NLM (2012); CTLA-4 Protein
Term UI T000999636
Date11/27/2019
LexicalTag ABX
ThesaurusID NLM (2021); Cytotoxic T-Lymphocyte Antigen 4
Term UI T787433
Date03/21/2011
LexicalTag NON
ThesaurusID NLM (2012); Antigens, CD152
Term UI T787434
Date03/21/2011
LexicalTag ABX
ThesaurusID NLM (2012); CD152 Antigen
Term UI T787435
Date03/21/2011
LexicalTag ABX
ThesaurusID NLM (2012); Cytotoxic T-Lymphocyte-Associated Antigen 4
Term UI T787437
Date03/21/2011
LexicalTag NON
ThesaurusID NLM (2012)

CTLA-4 Antigen MeSH Descriptor Data 2024