MeSH Browser

MeSH Heading: CD3 Complex
Tree Number(s): D23.050.301.264.894.095; D23.101.100.894.095
Unique ID: D017252
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D017252
Scope Note: Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Entry Term(s): Antigens, CD3; CD3 Antigen; CD3 Antigens; T3 Antigen; T3 Antigens; T3 Complex
Previous Indexing: Antigens (1983-1984); Antigens, Differentiation, T-Lymphocyte (1988-1992); Antigens, Surface (1983-1987); Receptors, Antigen, T-Cell (1990-1992)
See Also: Receptors, Antigen, T-Cell
Public MeSH Note: 2018; see ANTIGENS, CD3 1993-2017; CD3 COMPLEX was indexed under RECEPTORS, ANTIGEN, T-CELL 1990-92; under ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE 1988-92; under ANTIGENS, SURFACE 1983-87; and under ANTIGENS 1983-84; for T3 ANTIGENS see ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE 1988-92
History Note: 2018 (1993); use T3 ANTIGEN COMPLEX 1983-92; use ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE 1988-92
Date Established: 1993/01/01
Date of Entry: 1992/05/07
Revision Date: 2017/06/02

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Biological Factors [D23]
- Antigens [D23.050]
  - Antigens, Surface [D23.050.301]
    - Antigens, Differentiation [D23.050.301.264]
      - Antigens, Differentiation, T-Lymphocyte [D23.050.301.264.894]
        
        Antigens, CD1 [D23.050.301.264.894.080]
        
        CD2 Antigens [D23.050.301.264.894.090]
        
        T Lineage-Specific Activation Antigen 1 [D23.050.301.264.894.093]
        
        CD3 Complex [D23.050.301.264.894.095]
        
        Receptor-CD3 Complex, Antigen, T-Cell [D23.050.301.264.894.095.800]
        
        CD4 Antigens [D23.050.301.264.894.100]
        
        CD5 Antigens [D23.050.301.264.894.101]
        
        Antigens, CD7 [D23.050.301.264.894.107]
        
        CD8 Antigens [D23.050.301.264.894.108]
        
        CD13 Antigens [D23.050.301.264.894.113]
        
        CD18 Antigens [D23.050.301.264.894.118]
        
        Lymphocyte Activation Gene 3 Protein [D23.050.301.264.894.121]
        
        Thy-1 Antigens [D23.050.301.264.894.123]
        
        Tumor Necrosis Factor Receptor Superfamily, Member 7 [D23.050.301.264.894.127]
        
        CD28 Antigens [D23.050.301.264.894.128]
        
        CD56 Antigen [D23.050.301.264.894.156]
        
        CD57 Antigens [D23.050.301.264.894.157]
        
        CTLA-4 Antigen [D23.050.301.264.894.158]
        
        Dipeptidyl Peptidase 4 [D23.050.301.264.894.160]
        
        Inducible T-Cell Co-Stimulator Protein [D23.050.301.264.894.580]
        
        Programmed Cell Death 1 Receptor [D23.050.301.264.894.790]

Biological Factors [D23]
- Biomarkers [D23.101]
  - Antigens, Differentiation [D23.101.100]
    - Antigens, Differentiation, T-Lymphocyte [D23.101.100.894]

CD3 Complex Preferred

Concept UI: M0026174
Scope Note: Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Terms: CD3 Complex Preferred Term
Term UI T051429
Date12/30/1991
LexicalTag NON
ThesaurusID NLM (1993); T3 Antigen
Term UI T051424
Date12/30/1991
LexicalTag NON
ThesaurusID NLM (1993); T3 Antigens
Term UI T051425
Date12/30/1991
LexicalTag NON
ThesaurusID NLM (1993); CD3 Antigen
Term UI T051426
Date12/30/1991
LexicalTag NON
ThesaurusID NLM (1993); CD3 Antigens
Term UI T051427
Date12/30/1991
LexicalTag NON
ThesaurusID NLM (1993); Antigens, CD3
Term UI T051428
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1993); T3 Complex
Term UI T051430
Date12/30/1991
LexicalTag NON
ThesaurusID NLM (1993)

CD3 Complex MeSH Descriptor Data 2025