MeSH Browser

MeSH Heading: CD4 Antigens
Tree Number(s): D12.776.543.750.705.852.420.810.500; D12.776.543.750.830.700.025; D23.050.301.264.894.100; D23.101.100.894.100
Unique ID: D015704
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015704
Annotation: for hematodermic CD4/CD56 neoplasm use LYMPHOMA, NON-HODGKIN
Scope Note: 55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. They are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. T4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
Entry Term(s): Antigens, CD4; CD4 Antigen; CD4 Molecule; CD4 Receptor; CD4 Receptors; Receptors, CD4; Receptors, Surface CD4; Surface CD4 Receptor; T4 Antigens, T-Cell
NLM Classification #: QW 573
Previous Indexing: Antigens, Differentiation, T-Lymphocyte (1988-1989); Antigens, Surface (1979-1987); Receptors, Antigen, T-Cell (1980-1989); Receptors, Virus (1979-1989)
See Also: CD4-CD8 Ratio; HIV Envelope Protein gp120; Immunoglobulin Domains
Public MeSH Note: 2018; see ANTIGENS, CD4 1990-2017 and ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE 1989
History Note: 2018 (1989); use ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE 1989
Date Established: 1990/01/01
Date of Entry: 1989/06/19
Revision Date: 2021/06/30

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Receptors, Cytokine [D12.776.543.750.705.852]
        
        Receptors, Interleukin [D12.776.543.750.705.852.420]
        
        Receptors, Interleukin-16 [D12.776.543.750.705.852.420.810]
        
        CD4 Antigens [D12.776.543.750.705.852.420.810.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Virus [D12.776.543.750.830]
        
        Receptors, HIV [D12.776.543.750.830.700]
        
        CD4 Antigens [D12.776.543.750.830.700.025]
        
        CX3C Chemokine Receptor 1 [D12.776.543.750.830.700.315]
        
        Receptors, CCR5 [D12.776.543.750.830.700.605]
        
        Receptors, CXCR4 [D12.776.543.750.830.700.650]

Biological Factors [D23]
- Antigens [D23.050]
  - Antigens, Surface [D23.050.301]
    - Antigens, Differentiation [D23.050.301.264]
      - Antigens, Differentiation, T-Lymphocyte [D23.050.301.264.894]
        
        Antigens, CD1 [D23.050.301.264.894.080]
        
        CD2 Antigens [D23.050.301.264.894.090]
        
        T Lineage-Specific Activation Antigen 1 [D23.050.301.264.894.093]
        
        CD3 Complex [D23.050.301.264.894.095]
        
        CD4 Antigens [D23.050.301.264.894.100]
        
        CD5 Antigens [D23.050.301.264.894.101]
        
        Antigens, CD7 [D23.050.301.264.894.107]
        
        CD8 Antigens [D23.050.301.264.894.108]
        
        CD13 Antigens [D23.050.301.264.894.113]
        
        CD18 Antigens [D23.050.301.264.894.118]
        
        Lymphocyte Activation Gene 3 Protein [D23.050.301.264.894.121]
        
        Thy-1 Antigens [D23.050.301.264.894.123]
        
        Tumor Necrosis Factor Receptor Superfamily, Member 7 [D23.050.301.264.894.127]
        
        CD28 Antigens [D23.050.301.264.894.128]
        
        CD56 Antigen [D23.050.301.264.894.156]
        
        CD57 Antigens [D23.050.301.264.894.157]
        
        CTLA-4 Antigen [D23.050.301.264.894.158]
        
        Dipeptidyl Peptidase 4 [D23.050.301.264.894.160]
        
        Inducible T-Cell Co-Stimulator Protein [D23.050.301.264.894.580]
        
        Programmed Cell Death 1 Receptor [D23.050.301.264.894.790]

Biological Factors [D23]
- Biomarkers [D23.101]
  - Antigens, Differentiation [D23.101.100]
    - Antigens, Differentiation, T-Lymphocyte [D23.101.100.894]

CD4 Antigens Preferred

Concept UI: M0024088
Scope Note: 55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. They are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. T4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
Terms: CD4 Antigens Preferred Term
Term UI T046553
Date02/15/1989
LexicalTag NON
ThesaurusID NLM (1990); Receptors, CD4
Term UI T046557
Date05/06/1993
LexicalTag NON
ThesaurusID NLM (1994); Surface CD4 Receptor
Term UI T046558
Date02/15/1989
LexicalTag NON
ThesaurusID NLM (1990); Receptors, Surface CD4
Term UI T046559
Date05/06/1993
LexicalTag NON
ThesaurusID NLM (1994); T4 Antigens, T-Cell
Term UI T046560
Date04/27/1989
LexicalTag NON
ThesaurusID NLM (1990); CD4 Receptor
Term UI T001090066
Date10/14/2020
LexicalTag NON
ThesaurusID NLM (2022); CD4 Antigen
Term UI T046552
Date03/18/1992
LexicalTag NON
ThesaurusID NLM (1993); Antigens, CD4
Term UI T046554
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1990); CD4 Receptors
Term UI T046556
Date11/16/1990
LexicalTag NON
ThesaurusID NLM (1992); CD4 Molecule
Term UI T046555
Date02/15/1989
LexicalTag NON
ThesaurusID NLM (1990)

CD4 Antigens MeSH Descriptor Data 2025