MeSH Browser

MeSH Heading: B7-H1 Antigen
Tree Number(s): D12.776.465.625; D12.776.467.150.300; D12.776.543.095.300; D23.050.301.285.400; D23.529.168.300
Unique ID: D060890
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D060890
Scope Note: An inhibitory B7 antigen that contains V-type and C2 type immunoglobulin domains. It has specificity for the T-CELL receptor PROGRAMMED CELL DEATH 1 PROTEIN and provides negative signals that control and inhibit T-cell responses. It is found at higher than normal levels on tumor cells, suggesting its potential role in TUMOR IMMUNE EVASION.
Entry Term(s): Antigens, CD274; B7-H1 Immune Costimulatory Protein; B7H1 Immune Costimulatory Protein; CD274 Antigen; PD-L1 Costimulatory Protein; PD-L1 Protein; Programmed Cell Death 1 Ligand 1; Programmed Cell Death 1 Ligand 1 Protein; Programmed Death Ligand 1
Registry Number: 0
Previous Indexing: Antigens, CD (2007-2011); Antigens, CD80 (2001-2006); Blood Proteins (2001-2005)
See Also: Immunoglobulin Domains
Public MeSH Note: 2018; see ANTIGENS, CD274 2012-2017
History Note: 2018 (2007)
Date Established: 2012/01/01
Date of Entry: 2011/06/24
Revision Date: 2020/03/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Immune Checkpoint Proteins [D12.776.465]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - B7 Antigens [D12.776.467.150]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - B7 Antigens [D12.776.543.095]

Biological Factors [D23]
- Antigens [D23.050]
  - Antigens, Surface [D23.050.301]
    - B7 Antigens [D23.050.301.285]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]
  - B7 Antigens [D23.529.168]

B7-H1 Antigen Preferred

Concept UI: M0555734
Registry Number: 0
Scope Note: An inhibitory B7 antigen that contains V-type and C2 type immunoglobulin domains. It has specificity for the T-CELL receptor PROGRAMMED CELL DEATH 1 PROTEIN and provides negative signals that control and inhibit T-cell responses. It is found at higher than normal levels on tumor cells, suggesting its potential role in TUMOR IMMUNE EVASION.
Terms: B7-H1 Antigen Preferred Term
Term UI T788010
Date03/30/2011
LexicalTag ABX
ThesaurusID NLM (2012); Programmed Death Ligand 1
Term UI T000999640
Date11/27/2019
LexicalTag NON
ThesaurusID NLM (2021); Antigens, CD274
Term UI T787305
Date03/18/2011
LexicalTag ABX
ThesaurusID NLM (2012); CD274 Antigen
Term UI T788009
Date03/30/2011
LexicalTag ABX
ThesaurusID NLM (2012); B7-H1 Immune Costimulatory Protein
Term UI T787427
Date03/21/2011
LexicalTag ABX
ThesaurusID NLM (2012); B7H1 Immune Costimulatory Protein
Term UI T787428
Date03/21/2011
LexicalTag ABX
ThesaurusID NLM (2012); PD-L1 Costimulatory Protein
Term UI T787886
Date03/29/2011
LexicalTag ABX
ThesaurusID NLM (2012); Programmed Cell Death 1 Ligand 1 Protein
Term UI T787894
Date03/29/2011
LexicalTag NON
ThesaurusID NLM (2012); PD-L1 Protein
Term UI T000999639
Date11/27/2019
LexicalTag ABX
ThesaurusID NLM (2021); Programmed Cell Death 1 Ligand 1
Term UI T787426
Date03/21/2011
LexicalTag NON
ThesaurusID NLM (2012)

B7-H1 Antigen MeSH Descriptor Data 2023