MeSH Browser

MeSH Heading: B7-1 Antigen
Tree Number(s): D12.776.467.150.100; D12.776.543.095.100; D23.050.301.285.100; D23.529.168.100
Unique ID: D018122
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D018122
Scope Note: A costimulatory ligand membrane glycoprotein that contains a V2 type and C2 IMMUNOGLOBULIN DOMAIN and is expressed by ANTIGEN-PRESENTING CELLS. It binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Entry Term(s): Antigen, B7-1; Antigens, CD80; B-Cell Activation Antigen; B7-1 Costimulatory Molecule; B7-1 Ligand; CD80 Antigen; CD80 Antigens
Previous Indexing: Antigens, Surface (1991-1993)
Public MeSH Note: 2018; see ANTIGENS, CD80 1996-2017; see B-CELL ACTIVATION ANTIGEN 1994-95; B7-1 ANTIGEN was indexed under B-CELL ACTIVATION ANTIGEN 1994-95; B CELL ACTIVATION ANTIGEN B7 was indexed under ANTIGENS, SURFACE 1991-93
History Note: 2018 (1991)
Date Established: 1994/01/01
Date of Entry: 1993/06/04
Revision Date: 2017/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0027327
Scope Note: A costimulatory ligand membrane glycoprotein that contains a V2 type and C2 IMMUNOGLOBULIN DOMAIN and is expressed by ANTIGEN-PRESENTING CELLS. It binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Terms: B7-1 Antigen Preferred Term
Term UI T636317
Date04/12/2005
LexicalTag ABX
ThesaurusID NLM (2006); Antigen, B7-1
Term UI T636318
Date04/12/2005
LexicalTag ABX
ThesaurusID NLM (2006); B7-1 Ligand
Term UI T787921
Date03/29/2011
LexicalTag ABX
ThesaurusID NLM (2012); B-Cell Activation Antigen
Term UI T054231
Date01/26/1995
LexicalTag NON
ThesaurusID NLM (1996); CD80 Antigen
Term UI T054233
Date01/26/1995
LexicalTag ABX
ThesaurusID NLM (1996); CD80 Antigens
Term UI T054234
Date01/26/1995
LexicalTag ABX
ThesaurusID NLM (1996); Antigens, CD80
Term UI T054235
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1994); B7-1 Costimulatory Molecule
Term UI T054237
Date01/26/1995
LexicalTag ABX
ThesaurusID NLM (1996)

B7-1 Antigen MeSH Descriptor Data 2025