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B7-1 Antigen MeSH Descriptor Data 2023


MeSH Heading
B7-1 Antigen
Tree Number(s)
D12.776.467.150.100
D12.776.543.095.100
D23.050.301.285.100
D23.529.168.100
Unique ID
D018122
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D018122
Scope Note
A costimulatory ligand membrane glycoprotein that contains a V2 type and C2 IMMUNOGLOBULIN DOMAIN and is expressed by ANTIGEN-PRESENTING CELLS. It binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Entry Term(s)
Antigen, B7-1
Antigens, CD80
B-Cell Activation Antigen
B7-1 Costimulatory Molecule
B7-1 Ligand
CD80 Antigen
CD80 Antigens
Registry Number
0
Previous Indexing
Antigens, Surface (1991-1993)
Public MeSH Note
2018; see ANTIGENS, CD80 1996-2017; see B-CELL ACTIVATION ANTIGEN 1994-95; B7-1 ANTIGEN was indexed under B-CELL ACTIVATION ANTIGEN 1994-95; B CELL ACTIVATION ANTIGEN B7 was indexed under ANTIGENS, SURFACE 1991-93
History Note
2018 (1991)
Date Established
1994/01/01
Date of Entry
1993/06/04
Revision Date
2017/05/24
B7-1 Antigen Preferred
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