MeSH Browser

MeSH Heading: Immunoglobulin Fc Fragments
Tree Number(s): D12.644.541.500.697; D12.776.124.486.485.538.500; D12.776.124.486.485.680.697; D12.776.124.790.651.538.500; D12.776.124.790.651.680.660; D12.776.377.715.548.538.500; D12.776.377.715.548.680.660
Unique ID: D007141
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007141
Scope Note: Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
Entry Version: IG FC FRAGMENTS
Entry Term(s): Fc Fragment; Fc Fragments; Fc Immunoglobulin; Fc Immunoglobulins; Ig Fc Fragments; Immunoglobulin Fc Fragment; Immunoglobulins, Fc; Immunoglobulins, Fc Fragment
Pharm Action: Immunologic Factors
Registry Numbers: 0
Previous Indexing: Immunoglobulins (1970-1972)
See Also: Receptors, Fc
Public MeSH Note: 2006; see IMMUNOGLOBULINS, FC 1987-2005, see IMMUNOGLOBULIN FRAGMENTS 1984-1986, see IMMUNOGLOBULINS, FC 1973-1983
History Note: 2006 (1973)
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2021/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Peptide Fragments [D12.644.541]
    - Immunoglobulin Fragments [D12.644.541.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Immunoproteins [D12.776.124.486]
      - Immunoglobulins [D12.776.124.486.485]
        
        Immunoglobulin Constant Regions [D12.776.124.486.485.538]
        
        Immunoglobulin Fc Fragments [D12.776.124.486.485.538.500]
        
        CD4 Immunoadhesins [D12.776.124.486.485.538.500.249]
        
        Etanercept [D12.776.124.486.485.538.500.624]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Immunoproteins [D12.776.124.486]
      - Immunoglobulins [D12.776.124.486.485]
        
        Immunoglobulin Fragments [D12.776.124.486.485.680]
        
        Immunoglobulin Fab Fragments [D12.776.124.486.485.680.650]
        
        Immunoglobulin Fc Fragments [D12.776.124.486.485.680.697]
        
        CD4 Immunoadhesins [D12.776.124.486.485.680.697.249]
        
        Etanercept [D12.776.124.486.485.680.697.624]
        
        Immunoglobulin Idiotypes [D12.776.124.486.485.680.745]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Serum Globulins [D12.776.124.790]
      - Immunoglobulins [D12.776.124.790.651]
        
        Immunoglobulin Constant Regions [D12.776.124.790.651.538]
        
        Immunoglobulin Fc Fragments [D12.776.124.790.651.538.500]
        
        CD4 Immunoadhesins [D12.776.124.790.651.538.500.249]
        
        Etanercept [D12.776.124.790.651.538.500.624]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Serum Globulins [D12.776.124.790]
      - Immunoglobulins [D12.776.124.790.651]
        
        Immunoglobulin Fragments [D12.776.124.790.651.680]
        
        Immunoglobulin Fab Fragments [D12.776.124.790.651.680.650]
        
        Immunoglobulin Fc Fragments [D12.776.124.790.651.680.660]
        
        CD4 Immunoadhesins [D12.776.124.790.651.680.660.249]
        
        Etanercept [D12.776.124.790.651.680.660.624]
        
        Immunoglobulin Idiotypes [D12.776.124.790.651.680.745]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Globulins [D12.776.377]
    - Serum Globulins [D12.776.377.715]
      - Immunoglobulins [D12.776.377.715.548]
        
        Immunoglobulin Constant Regions [D12.776.377.715.548.538]
        
        Immunoglobulin Fc Fragments [D12.776.377.715.548.538.500]
        
        CD4 Immunoadhesins [D12.776.377.715.548.538.500.249]
        
        Etanercept [D12.776.377.715.548.538.500.624]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Globulins [D12.776.377]
    - Serum Globulins [D12.776.377.715]
      - Immunoglobulins [D12.776.377.715.548]
        
        Immunoglobulin Fragments [D12.776.377.715.548.680]
        
        Immunoglobulin Fab Fragments [D12.776.377.715.548.680.650]
        
        Immunoglobulin Fc Fragments [D12.776.377.715.548.680.660]
        
        CD4 Immunoadhesins [D12.776.377.715.548.680.660.249]
        
        Etanercept [D12.776.377.715.548.680.660.624]
        
        Immunoglobulin Idiotypes [D12.776.377.715.548.680.745]

Immunoglobulin Fc Fragments Preferred

Concept UI: M0011127
Registry Numbers: 0
Scope Note: Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
Terms: Immunoglobulin Fc Fragments Preferred Term
Term UI T633966
Date03/22/2005
LexicalTag NON
ThesaurusID NLM (2006); Fc Fragment
Term UI T001088269
Date09/08/2020
LexicalTag NON
ThesaurusID NLM (2022); Ig Fc Fragments
Term UI T000962318
Date06/25/2019
LexicalTag ABX
ThesaurusID NLM (2020); Fc Fragments
Term UI T021384
Date03/30/1974
LexicalTag NON
ThesaurusID UNK (19XX); Fc Immunoglobulins
Term UI T021385
Date03/18/1991
LexicalTag NON
ThesaurusID NLM (1992); Immunoglobulin Fc Fragment
Term UI T633967
Date03/22/2005
LexicalTag NON
ThesaurusID NLM (2006); Immunoglobulins, Fc
Term UI T021386
Date01/01/1999
LexicalTag ABX
ThesaurusID NLM (1973); Fc Immunoglobulin
Term UI T001088268
Date09/08/2020
LexicalTag NON
ThesaurusID NLM (2022); Immunoglobulins, Fc Fragment
Term UI T634184
Date03/23/2005
LexicalTag NON
ThesaurusID NLM (2006)

Immunoglobulin Fc Fragments MeSH Descriptor Data 2025