MeSH Browser

MeSH Heading: Immunoglobulin Fab Fragments
Tree Number(s): D12.644.541.500.650; D12.776.124.486.485.680.650; D12.776.124.790.651.680.650; D12.776.377.715.548.680.650
Unique ID: D007140
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007140
Scope Note: Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
Entry Version: IG FAB FRAGMENTS
Entry Term(s): Fab Fragment; Fab Fragments; Fab Immunoglobulin Fragments; Ig Fab Fragments; Immunoglobulin Fab Fragment; Immunoglobulins, Fab; Immunoglobulins, Fab Fragment
Pharm Action: Immunologic Factors
Previous Indexing: Immunoglobulins (1970-1972)
Public MeSH Note: 2006; was IMMUNOGLOBULINS, FAB 1973-2005
History Note: 2006 (1973)
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0011126
Scope Note: Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
Terms: Immunoglobulin Fab Fragments Preferred Term
Term UI T633956
Date03/22/2005
LexicalTag NON
ThesaurusID NLM (2006); Ig Fab Fragments
Term UI T000962317
Date06/25/2019
LexicalTag ABX
ThesaurusID NLM (2020); Fab Fragments
Term UI T021383
Date03/15/1991
LexicalTag NON
ThesaurusID NLM (1992); Immunoglobulins, Fab
Term UI T021382
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1973); Immunoglobulin Fab Fragment
Term UI T633959
Date03/22/2005
LexicalTag NON
ThesaurusID NLM (2006); Fab Immunoglobulin Fragments
Term UI T634137
Date03/23/2005
LexicalTag NON
ThesaurusID NLM (2006); Immunoglobulins, Fab Fragment
Term UI T634138
Date03/23/2005
LexicalTag NON
ThesaurusID NLM (2006); Fab Fragment
Term UI T001081132
Date05/22/2020
LexicalTag NON
ThesaurusID NLM (2021)

Immunoglobulin Fab Fragments MeSH Descriptor Data 2025