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In Situ Nick-End Labeling MeSH Descriptor Data 2023


MeSH Heading
In Situ Nick-End Labeling
Tree Number(s)
E05.393.475
Unique ID
D020287
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D020287
Scope Note
An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.
Entry Term(s)
In Situ Nick End Labeling
In Situ Nick End Labelling
In Situ Nick End-Labeling
In Situ Nick End-Labelling
In Situ Nick-End Labelling
Nick End-Labeling, In Situ
Nick End-Labelling, In Situ
Nick-End Labeling, In Situ
Nick-End Labelling, In Situ
TUNEL
Previous Indexing
Apoptosis (1994-1998)
See Also
Apoptosis
Comet Assay
Public MeSH Note
99
History Note
99
Date Established
1999/01/01
Date of Entry
1998/06/10
Revision Date
2006/07/05
In Situ Nick-End Labeling Preferred
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