the discipline; also used for epidemiologic application of molecular biology (NIM, no qualifiers); prefer specific epidemiologic concept & specific molecular or genetic concept (IM) coordinated with main headings /epidemiol (IM) & /genet (IM), as "molecular epidemiology of rabies virus in France" = RABIES VIRUS/genet (IM) + RNA, VIRAL/genet (NIM) (molecular aspect from text) + RABIES/epidemiol (IM) (epidemiologic aspect from text) + FRANCE/epidemiol (NIM)
Scope Note
The application of molecular biology to the answering of epidemiological questions. The examination of patterns of changes in DNA to implicate particular carcinogens and the use of molecular markers to predict which individuals are at highest risk for a disease are common examples.
The application of molecular biology to the answering of epidemiological questions. The examination of patterns of changes in DNA to implicate particular carcinogens and the use of molecular markers to predict which individuals are at highest risk for a disease are common examples.
The epidemiological evaluation of the role of inherited causes of disease in families and in populations; it aims to detect the inheritance pattern of a particular disease, localize the gene and find a marker associated with disease susceptibility. Gene-gene and gene-environment interactions are also studied in genetic epidemiology of a disease. In its broad context, genetic epidemiology includes family studies, molecular epidemiologic studies with genetic components, and more traditional cohort and case-control studies with family history components.
