- Concept UI
- M000613853
- Registry Numbers
- 0
- Scope Note
- A transcriptional co-activator for NUCLEAR RECEPTORS. It is characterized by an N-terminal LxxLL sequence, a region that interacts with PPAR GAMMA, and a C-terminal RNA RECOGNITION MOTIF. It increases expression of MITOCHONDRIAL UNCOUPLING PROTEIN to regulate genes involved in metabolic reprogramming in response to dietary restriction and the integration of CIRCADIAN RHYTHMS with ENERGY METABOLISM.
- Terms
-
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Preferred Term
Term UI
T000894248
Date01/27/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
PPARGC-1-alpha Protein
Term UI
T000894246
Date01/27/2016
LexicalTag
ABX
ThesaurusID
NLM (2017)
-
PGC-1-alpha Protein
Term UI
T000894247
Date01/27/2016
LexicalTag
ABX
ThesaurusID
NLM (2017)
-
PPARGC1a Protein
Term UI
T000894276
Date01/27/2016
LexicalTag
ABX
ThesaurusID
NLM (2017)