MeSH Browser

MeSH Heading: Dentin Sialophosphoprotein
Tree Number(s): D09.400.430.950.001; D12.644.233.800.001; D12.776.395.700.001; D12.776.744.001; D12.776.860.300.531
Unique ID: D000099311
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000099311
Scope Note: An extracellular matrix protein that is highly expressed in ODONTOBLASTS. It is cleaved into 2 chains: dentin sialoprotein and dentin phosphoprotein. Mutations in the human DSPP gene, which encodes dentin sialophosphoprotein, can cause DENTINOGENESIS IMPERFECTA.
Entry Term(s): Dentin Matrix Protein 3; Dentin Phosphophoryn; Dentin Phosphoprotein; Dentin Sialoprotein
Registry Numbers: 0
Public MeSH Note: 2026; DENTIN SIALOPHOSPHOPROTEIN was indexed under EXTRACELLULAR MATRIX PROTEINS; PHOSPHOPROTEINS; SIALOGLYCOPROTEINS 2000-2025
History Note: 2026 (2000)
Date Introduced: 2026/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000769215
Registry Numbers: 0
Scope Note: An extracellular matrix protein that is highly expressed in ODONTOBLASTS. It is cleaved into 2 chains: dentin sialoprotein and dentin phosphoprotein. Mutations in the human DSPP gene, which encodes dentin sialophosphoprotein, can cause DENTINOGENESIS IMPERFECTA.
Terms: Dentin Sialophosphoprotein Preferred Term
Term UI T001149249
Date07/09/2025
LexicalTag NON
ThesaurusID NLM (2026); Dentin Matrix Protein 3
Term UI T001149250
Date07/09/2025
LexicalTag NON
ThesaurusID NLM (2026); Dentin Phosphophoryn
Term UI T001149252
Date07/09/2025
LexicalTag NON
ThesaurusID NLM (2026); Dentin Phosphoprotein
Term UI T001149251
Date07/09/2025
LexicalTag NON
ThesaurusID NLM (2026); Dentin Sialoprotein
Term UI T001149253
Date07/09/2025
LexicalTag NON
ThesaurusID NLM (2026)

Dentin Sialophosphoprotein MeSH Descriptor Data 2026