MeSH Browser

MeSH Heading: Small Leucine-Rich Proteoglycans
Tree Number(s): D09.400.430.930.875; D09.698.735.700; D12.776.395.650.875; D12.776.860.300.806
Unique ID: D000071232
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071232
Scope Note: A proteoglycan family (SLRPs) that is defined by a central domain which consists of a variable number of repeats of the motif LXXLxLXXNxL, where L may be LEUCINE; ISOLEUCINE; VALINE; or other hydrophobic amino acids. The N-terminal contains four conserved CYSTEINE residues and may be modified depending on function. SLRPs provide structural support to the EXTRACELLULAR MATRIX and are critical for regulating its assembly and dynamics at CELL-MATRIX JUNCTIONS.
Entry Term(s): SLRP Proteoglycan; SLRP Proteoglycans; Small Leucine Rich Proteoglycan; Small Leucine-Rich Proteoglycan; Small Leucine-Rich Repeat Proteoglycan; Small Leucine-Rich Repeat Proteoglycans
Previous Indexing: Proteoglycans (1996-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000613763
Scope Note: A proteoglycan family (SLRPs) that is defined by a central domain which consists of a variable number of repeats of the motif LXXLxLXXNxL, where L may be LEUCINE; ISOLEUCINE; VALINE; or other hydrophobic amino acids. The N-terminal contains four conserved CYSTEINE residues and may be modified depending on function. SLRPs provide structural support to the EXTRACELLULAR MATRIX and are critical for regulating its assembly and dynamics at CELL-MATRIX JUNCTIONS.
Terms: Small Leucine-Rich Proteoglycans Preferred Term
Term UI T000894008
Date01/22/2016
LexicalTag NON
ThesaurusID NLM (2017); Small Leucine-Rich Repeat Proteoglycan
Term UI T000894005
Date01/22/2016
LexicalTag NON
ThesaurusID NLM (2017); SLRP Proteoglycans
Term UI T000894006
Date01/22/2016
LexicalTag ABX
ThesaurusID NLM (2017); Small Leucine-Rich Repeat Proteoglycans
Term UI T000894004
Date01/22/2016
LexicalTag NON
ThesaurusID NLM (2017); Small Leucine Rich Proteoglycan
Term UI T000998443
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); Small Leucine-Rich Proteoglycan
Term UI T000998444
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); SLRP Proteoglycan
Term UI T000998445
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021)

Small Leucine-Rich Proteoglycans MeSH Descriptor Data 2025