MeSH Browser

MeSH Heading: Proteoglycan 4
Tree Number(s): D09.400.430.930.613; D09.698.735.550; D12.776.395.650.613
Unique ID: D000099158
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000099158
Scope Note: A proteoglycan involved in joint surface lubrication and encoded by the PRG4 gene. Altered expression occurs in some forms of ARTHRITIS.
Entry Term(s): Lubricating Glycoprotein-I; Lubricin; PRG4 Protein
Registry Numbers: 0
Public MeSH Note: 2026 (1985); see LUBRICIN 1985-2025; was indexed under GLYCOPROTEINS 1985-2025
History Note: 2026 (1985); was LUBRICIN 1985-2025
Date Introduced: 2026/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000768825
Registry Numbers: 0
Scope Note: A proteoglycan involved in joint surface lubrication and encoded by the PRG4 gene. Altered expression occurs in some forms of ARTHRITIS.
Terms: Proteoglycan 4 Preferred Term
Term UI T001147447
Date03/17/2025
LexicalTag NON
ThesaurusID NLM (2026); Lubricating Glycoprotein-I
Term UI T001147693
Date03/26/2025
LexicalTag NON
ThesaurusID NLM (2026); Lubricin
Term UI T001147694
Date03/26/2025
LexicalTag NON
ThesaurusID NLM (2026); PRG4 Protein
Term UI T001148446
Date05/08/2025
LexicalTag NON
ThesaurusID NLM (2026)

Proteoglycan 4 MeSH Descriptor Data 2026