MeSH Browser

MeSH Heading: Antigens, Polyomavirus Transforming
Tree Number(s): D12.776.624.664.520.090; D12.776.964.350.062.090; D12.776.964.700.090; D23.050.285.062.090; D23.050.327.062.090
Unique ID: D000952
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000952
Annotation: coordinate with specific polyoma virus /‌immunol
Scope Note: Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
Entry Version: PVTA
Entry Term(s): Polyomavirus Large T Antigens; Polyomavirus Middle T Antigens; Polyomavirus Small T Antigens; Polyomavirus T Proteins; Polyomavirus Transforming Antigens; Polyomavirus Tumor Antigens; Polyomaviruses Large T Proteins; Polyomaviruses Middle T Proteins; Polyomaviruses Small T Proteins; SV40 T Antigens; SV40 T Proteins; Simian Sarcoma Virus Proteins
Previous Indexing: Antigens, Viral (1973-1983); Antigens, Viral, Tumor (1984-1987); Oncogene Proteins, Viral (1986-1987); Viral Proteins (1966-1985)
Public MeSH Note: 88
History Note: 88
Date Established: 1988/01/01
Date of Entry: 1987/05/07
Revision Date: 2022/04/13

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0001437
Scope Note: Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
Terms: Antigens, Polyomavirus Transforming Preferred Term
Term UI T002883
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1988); Polyomavirus Transforming Antigens
Term UI T002882
Date05/07/1987
LexicalTag NON
ThesaurusID UNK (19XX); Polyomavirus Tumor Antigens
Term UI T002884
Date05/07/1987
LexicalTag NON
ThesaurusID UNK (19XX)

Antigens, Polyomavirus Transforming MeSH Descriptor Data 2025