Caspase 8 MeSH Descriptor Data 2025

MeSH Heading: Caspase 8
Tree Number(s): D08.811.277.656.262.500.126.550.800; D08.811.277.656.300.200.126.550.800; D12.776.157.057.018.037; D12.776.476.024.320.025; D12.776.476.075.405.550.800; D12.776.476.075.421.037
Unique ID: D053181
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053181
Scope Note: A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.
Entry Term(s): CAP4 Protease; Caspase-8; FLICE Protein; MACH Protein; Mch5 Protease; Pro-Caspase-8; Procaspase-8
Registry Numbers: EC 3.4.22.-; 0
See Also: Autoimmune Lymphoproliferative Syndrome
Public MeSH Note: 2007; CASPASE 8 was indexed under CASPASES 1999-2006 & under CYSTEINE PROTEINASES 1997-1998
History Note: 2007(2000)
Entry Combination: antagonists & inhibitors:Caspase Inhibitors; deficiency:Alstrom Syndrome
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2021/06/28

Entry Combination: antagonists & inhibitors:Caspase Inhibitors; deficiency:Alstrom Syndrome
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Cysteine Proteases [D08.811.277.656.262]
        
        Cysteine Endopeptidases [D08.811.277.656.262.500]
        
        Caspases [D08.811.277.656.262.500.126]
        
        Caspases, Initiator [D08.811.277.656.262.500.126.550]
        
        Caspase 1 [D08.811.277.656.262.500.126.550.100]
        
        Caspase 2 [D08.811.277.656.262.500.126.550.200]
        
        Caspase 8 [D08.811.277.656.262.500.126.550.800]
        
        Caspase 9 [D08.811.277.656.262.500.126.550.900]
        
        Caspase 10 [D08.811.277.656.262.500.126.550.910]
        
        Caspase 12 [D08.811.277.656.262.500.126.550.920]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Endopeptidases [D08.811.277.656.300]
        
        Cysteine Endopeptidases [D08.811.277.656.300.200]
        
        Caspases [D08.811.277.656.300.200.126]
        
        Caspases, Initiator [D08.811.277.656.300.200.126.550]
        
        Caspase 1 [D08.811.277.656.300.200.126.550.100]
        
        Caspase 2 [D08.811.277.656.300.200.126.550.200]
        
        Caspase 8 [D08.811.277.656.300.200.126.550.800]
        
        Caspase 9 [D08.811.277.656.300.200.126.550.900]
        
        Caspase 10 [D08.811.277.656.300.200.126.550.910]
        
        Caspase 12 [D08.811.277.656.300.200.126.550.920]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Adaptor Proteins, Signal Transducing [D12.776.157.057]
      - Death Domain Receptor Signaling Adaptor Proteins [D12.776.157.057.018]
        
        CASP8 and FADD-Like Apoptosis Regulating Protein [D12.776.157.057.018.024]
        
        Caspase 8 [D12.776.157.057.018.037]
        
        CRADD Signaling Adaptor Protein [D12.776.157.057.018.050]
        
        Edar-Associated Death Domain Protein [D12.776.157.057.018.100]
        
        Fas-Associated Death Domain Protein [D12.776.157.057.018.200]
        
        Receptor-Interacting Protein Serine-Threonine Kinases [D12.776.157.057.018.400]
        
        TNF Receptor-Associated Death Domain Protein [D12.776.157.057.018.600]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Adaptor Proteins, Signal Transducing [D12.776.476.024]
      - Death Domain Receptor Signaling Adaptor Proteins [D12.776.476.024.320]
        
        Caspase 8 [D12.776.476.024.320.025]
        
        CRADD Signaling Adaptor Protein [D12.776.476.024.320.050]
        
        Edar-Associated Death Domain Protein [D12.776.476.024.320.100]
        
        Fas-Associated Death Domain Protein [D12.776.476.024.320.550]
        
        Receptor-Interacting Protein Serine-Threonine Kinases [D12.776.476.024.320.662]
        
        TNF Receptor-Associated Death Domain Protein [D12.776.476.024.320.775]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Apoptosis Regulatory Proteins [D12.776.476.075]
      - Caspases [D12.776.476.075.405]
        
        Caspases, Initiator [D12.776.476.075.405.550]
        
        Caspase 1 [D12.776.476.075.405.550.100]
        
        Caspase 2 [D12.776.476.075.405.550.200]
        
        Caspase 8 [D12.776.476.075.405.550.800]
        
        Caspase 9 [D12.776.476.075.405.550.900]
        
        Caspase 10 [D12.776.476.075.405.550.910]
        
        Caspase 12 [D12.776.476.075.405.550.920]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Apoptosis Regulatory Proteins [D12.776.476.075]
      - Death Domain Receptor Signaling Adaptor Proteins [D12.776.476.075.421]
        
        CASP8 and FADD-Like Apoptosis Regulating Protein [D12.776.476.075.421.024]
        
        Caspase 8 [D12.776.476.075.421.037]
        
        CRADD Signaling Adaptor Protein [D12.776.476.075.421.050]
        
        Edar-Associated Death Domain Protein [D12.776.476.075.421.100]
        
        Fas-Associated Death Domain Protein [D12.776.476.075.421.200]
        
        Receptor-Interacting Protein Serine-Threonine Kinases [D12.776.476.075.421.400]
        
        TNF Receptor-Associated Death Domain Protein [D12.776.476.075.421.600]

Caspase 8 Preferred

Concept UI: M0283158
Registry Numbers: EC 3.4.22.-
Scope Note: A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.
Terms: Caspase 8 Preferred Term
Term UI T313163
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007); CAP4 Protease
Term UI T313158
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2007); FLICE Protein
Term UI T313159
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2007); MACH Protein
Term UI T313160
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2007); Mch5 Protease
Term UI T313161
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2007); Caspase-8
Term UI T313162
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007)

Procaspase-8 Narrower

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