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Caspase 1 MeSH Descriptor Data 2023


MeSH Heading
Caspase 1
Tree Number(s)
D08.811.277.656.262.500.126.550.100
D08.811.277.656.300.200.126.550.100
D12.776.476.075.405.550.100
Unique ID
D020170
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D020170
Scope Note
A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.
Entry Term(s)
CASP1 Caspase
ICE Protease
IL-1 beta Convertase
IL-1 beta-Converting Enzyme
IL1BC Enzyme
Interleukin-1 Converting Enzyme
Interleukin-1beta Converting Enzyme
Pro-Caspase-1
Procaspase-1
Registry Number
EC 3.4.22.36
Previous Indexing
Cysteine Proteinases (1995-1998)
Metalloproteinases (1989-1994)
See Also
Apoptosis
Interleukin-1
Public MeSH Note
99; INTERLEUKIN 1BETA CONVERTING ENZYME (now CASPASE 1) was indexed under CYSTEINE PROTEINASES 1995-98 & METALLOPROTEINASES 1989-94
History Note
99; use CASPASE 1 (NM) 1989-98
Entry Combination
antagonists & inhibitors:Caspase Inhibitors
Date Established
1999/01/01
Date of Entry
1998/06/10
Revision Date
2021/05/21
Caspase 1 Preferred
Procaspase-1 Narrower
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