MeSH Browser

MeSH Heading: Caspase 1
Tree Number(s): D08.811.277.656.262.500.126.550.100; D08.811.277.656.300.200.126.550.100; D12.776.476.075.405.550.100
Unique ID: D020170
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020170
Scope Note: A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.
Entry Term(s): CASP1 Caspase; ICE Protease; IL-1 beta Convertase; IL-1 beta-Converting Enzyme; IL1BC Enzyme; Interleukin-1 Converting Enzyme; Interleukin-1beta Converting Enzyme; Pro-Caspase-1; Procaspase-1
Previous Indexing: Cysteine Proteinases (1995-1998); Metalloproteinases (1989-1994)
See Also: Apoptosis; Interleukin-1
Public MeSH Note: 1999; INTERLEUKIN 1BETA CONVERTING ENZYME (now CASPASE 1) was indexed under CYSTEINE PROTEINASES 1995-1998 & METALLOPROTEINASES 1989-1994
History Note: 1999; use CASPASE 1 (NM) 1989-1998
Entry Combination: antagonists & inhibitors:Caspase Inhibitors
Date Established: 1999/01/01
Date of Entry: 2024/08/09
Revision Date: 2024/05/28

Entry Combination: antagonists & inhibitors:Caspase Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0029892
Scope Note: A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.
Terms: Caspase 1 Preferred Term
Term UI T059969
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1999); CASP1 Caspase
Term UI T658650
Date11/17/2005
LexicalTag ABX
ThesaurusID NLM (2007); ICE Protease
Term UI T059967
Date04/08/1998
LexicalTag ABX
ThesaurusID NLM (1999); IL-1 beta Convertase
Term UI T059970
Date01/16/1998
LexicalTag NON
ThesaurusID NLM (1999); IL-1 beta-Converting Enzyme
Term UI T059968
Date03/09/1998
LexicalTag NON
ThesaurusID NLM (1999); IL1BC Enzyme
Term UI T658651
Date11/17/2005
LexicalTag ABX
ThesaurusID NLM (2007); Interleukin-1 Converting Enzyme
Term UI T059965
Date01/16/1998
LexicalTag NON
ThesaurusID NLM (1999); Interleukin-1beta Converting Enzyme
Term UI T059966
Date01/16/1998
LexicalTag NON
ThesaurusID NLM (1999)

Caspase 1 MeSH Descriptor Data 2025