MeSH Browser

MeSH Heading: AlkB Homolog 1, Histone H2a Dioxygenase
Tree Number(s): D08.811.074.062.500; D08.811.682.690.416.139.500
Unique ID: D000071498
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071498
Scope Note: A dioxygenase and alkylation repair homolog that functions by oxidative demethylation in RNA and DNA REPAIR of substrates which contain 3-methylcytosine. It also functions as one of the HISTONE DEMETHYLASES involved in embryonic development and maintaining the pluripotency of EMBRYONIC STEM CELLS.
Entry Term(s): ALKBH Protein; Alkylated DNA Repair Protein AlkB Homolog 1; Alpha-Ketoglutarate-Dependent Dioxygenase ABH1; DNA Lyase ABH1; DNA Oxidative Demethylase ALKBH1
Previous Indexing: DNA Repair Enzymes (2005-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/06
Revision Date: 2016/04/15

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000614940
Scope Note: A dioxygenase and alkylation repair homolog that functions by oxidative demethylation in RNA and DNA REPAIR of substrates which contain 3-methylcytosine. It also functions as one of the HISTONE DEMETHYLASES involved in embryonic development and maintaining the pluripotency of EMBRYONIC STEM CELLS.
Terms: AlkB Homolog 1, Histone H2a Dioxygenase Preferred Term
Term UI T000895775
Date02/23/2016
LexicalTag ABX
ThesaurusID NLM (2017); DNA Oxidative Demethylase ALKBH1
Term UI T000895718
Date02/22/2016
LexicalTag ABX
ThesaurusID NLM (2017); Alkylated DNA Repair Protein AlkB Homolog 1
Term UI T000895719
Date02/22/2016
LexicalTag ABX
ThesaurusID NLM (2017); Alpha-Ketoglutarate-Dependent Dioxygenase ABH1
Term UI T000895721
Date02/22/2016
LexicalTag ABX
ThesaurusID NLM (2017); DNA Lyase ABH1
Term UI T000895722
Date02/22/2016
LexicalTag ABX
ThesaurusID NLM (2017); ALKBH Protein
Term UI T000895723
Date02/22/2016
LexicalTag ABX
ThesaurusID NLM (2017)

AlkB Homolog 1, Histone H2a Dioxygenase MeSH Descriptor Data 2025