MeSH Browser

MeSH Heading: AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase
Tree Number(s): D08.811.074.062.750; D08.811.682.690.416.139.750
Unique ID: D000071499
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071499
Scope Note: A dioxygenase and alkylation repair homolog that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. It can also repair alkylated DNA containing 1-ethenoadenine in vitro. It has highest affinity for double-stranded DNA.
Entry Term(s): Alkylated DNA Repair Protein AlkB Homolog 2; Alpha-ketoglutarate-Dependent Dioxygenase AlkB Homolog 2; DNA Oxidative Demethylase ALKBH2; Oxy DC1 Protein
Previous Indexing: Dioxygenases (2004-2016); DNA Repair Enzymes (2004-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/06
Revision Date: 2016/04/15

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000614941
Scope Note: A dioxygenase and alkylation repair homolog that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. It can also repair alkylated DNA containing 1-ethenoadenine in vitro. It has highest affinity for double-stranded DNA.
Terms: AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase Preferred Term
Term UI T000895774
Date02/23/2016
LexicalTag ABX
ThesaurusID NLM (2017); DNA Oxidative Demethylase ALKBH2
Term UI T000895725
Date02/22/2016
LexicalTag ABX
ThesaurusID NLM (2017); Alkylated DNA Repair Protein AlkB Homolog 2
Term UI T000895726
Date02/22/2016
LexicalTag ABX
ThesaurusID NLM (2017); Alpha-ketoglutarate-Dependent Dioxygenase AlkB Homolog 2
Term UI T000895728
Date02/22/2016
LexicalTag ABX
ThesaurusID NLM (2017); Oxy DC1 Protein
Term UI T000895729
Date02/22/2016
LexicalTag ABX
ThesaurusID NLM (2017)

AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase MeSH Descriptor Data 2025