MeSH Browser

MeSH Heading: Squalene Monooxygenase
Tree Number(s): D08.811.682.690.708.749
Unique ID: D050603
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D050603
Scope Note: The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the first oxygenation step in the biosynthesis of STEROLS and is thought to be a rate limiting enzyme in this pathway. Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide.
Entry Term(s): Squalene Epoxidase; Squalene Monooxygenase (2,3-Epoxidizing)
Related Numbers: 9029-62-3
Public MeSH Note: 2006; SQUALENE MONOOXYGENASE was indexed under OXYGENASES 1981-2005 & ETHERS, CYCLIC 1970-1980
History Note: 2006(1980); use ETHERS, CYCLIC 1970-1979
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2016/06/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0079002
Related Numbers: 9029-62-3
Scope Note: The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the first oxygenation step in the biosynthesis of STEROLS and is thought to be a rate limiting enzyme in this pathway. Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide.
Terms: Squalene Monooxygenase Preferred Term
Term UI T620744
Date11/30/2004
LexicalTag NON
ThesaurusID NLM (2006); Squalene Epoxidase
Term UI T109004
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Squalene Monooxygenase (2,3-Epoxidizing)
Term UI T109005
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006)

Squalene Monooxygenase MeSH Descriptor Data 2025