MeSH Browser

MeSH Heading: Cytochrome P450 Family 46
Tree Number(s): D08.244.453.875; D08.811.682.690.708.170.497; D12.776.422.220.453.875
Unique ID: D000072503
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000072503
Scope Note: A cytochrome P450 enzyme family that includes CHOLESTEROL 24-HYDROXYLASE, which is expressed primarily in the brain and functions in CHOLESTEROL metabolism.
Entry Term(s): CYP46; CYP46 Enzymes; CYP46 Family; Cytochrome P-450 CYP46
Registry Number: EC 1.14.14.25
Previous Indexing: Steroid Hydroxylases (1999-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Cytochrome P-450 CYP2J2 [D08.811.682.690.708.170.005]
        
        Aryl Hydrocarbon Hydroxylases [D08.811.682.690.708.170.010]
        
        Camphor 5-Monooxygenase [D08.811.682.690.708.170.012]
        
        Cytochrome P450 Family 1 [D08.811.682.690.708.170.020]
        
        Cytochrome P450 Family 11 [D08.811.682.690.708.170.425]
        
        Cytochrome P450 Family 12 [D08.811.682.690.708.170.438]
        
        Cytochrome P450 Family 17 [D08.811.682.690.708.170.444]
        
        Cytochrome P450 Family 19 [D08.811.682.690.708.170.447]
        
        Cytochrome P450 Family 2 [D08.811.682.690.708.170.450]
        
        Cytochrome P450 Family 21 [D08.811.682.690.708.170.463]
        
        Cytochrome P450 Family 24 [D08.811.682.690.708.170.469]
        
        Cytochrome P450 Family 26 [D08.811.682.690.708.170.485]
        
        Cytochrome P450 Family 27 [D08.811.682.690.708.170.493]
        
        Cytochrome P450 Family 3 [D08.811.682.690.708.170.495]
        
        Cytochrome P450 Family 4 [D08.811.682.690.708.170.496]
        
        Cytochrome P450 Family 46 [D08.811.682.690.708.170.497]
        
        Cholesterol 24-Hydroxylase [D08.811.682.690.708.170.497.500]
        
        Cytochrome P450 Family 51 [D08.811.682.690.708.170.499]
        
        Cytochrome P450 Family 6 [D08.811.682.690.708.170.880]
        
        Cytochrome P450 Family 7 [D08.811.682.690.708.170.890]
        
        Cytochrome P450 Family 8 [D08.811.682.690.708.170.900]
        
        Steroid Hydroxylases [D08.811.682.690.708.170.915]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Cytochrome P-450 CYP2J2 [D12.776.422.220.453.005]
        
        Aryl Hydrocarbon Hydroxylases [D12.776.422.220.453.010]
        
        Camphor 5-Monooxygenase [D12.776.422.220.453.012]
        
        Cytochrome P450 Family 1 [D12.776.422.220.453.100]
        
        Cytochrome P450 Family 11 [D12.776.422.220.453.484]
        
        Cytochrome P450 Family 12 [D12.776.422.220.453.485]
        
        Cytochrome P450 Family 17 [D12.776.422.220.453.487]
        
        Cytochrome P450 Family 19 [D12.776.422.220.453.489]
        
        Cytochrome P450 Family 2 [D12.776.422.220.453.491]
        
        Cytochrome P450 Family 21 [D12.776.422.220.453.493]
        
        Cytochrome P450 Family 24 [D12.776.422.220.453.496]
        
        Cytochrome P450 Family 26 [D12.776.422.220.453.498]
        
        Cytochrome P450 Family 27 [D12.776.422.220.453.499]
        
        Cytochrome P450 Family 3 [D12.776.422.220.453.860]
        
        Cytochrome P450 Family 4 [D12.776.422.220.453.870]
        
        Cytochrome P450 Family 46 [D12.776.422.220.453.875]
        
        Cholesterol 24-Hydroxylase [D12.776.422.220.453.875.500]
        
        Cytochrome P450 Family 51 [D12.776.422.220.453.878]
        
        Cytochrome P450 Family 6 [D12.776.422.220.453.880]
        
        Cytochrome P450 Family 7 [D12.776.422.220.453.890]
        
        Cytochrome P450 Family 8 [D12.776.422.220.453.900]
        
        Steroid Hydroxylases [D12.776.422.220.453.915]

Cytochrome P450 Family 46 Preferred

Concept UI: M000617236
Registry Number: EC 1.14.14.25
Scope Note: A cytochrome P450 enzyme family that includes CHOLESTEROL 24-HYDROXYLASE, which is expressed primarily in the brain and functions in CHOLESTEROL metabolism.
Terms: Cytochrome P450 Family 46 Preferred Term
Term UI T000899828
Date04/26/2016
LexicalTag NON
ThesaurusID NLM (2017); CYP46
Term UI T475880
Date01/04/2002
LexicalTag ABB
ThesaurusID NLM (2002); Cytochrome P-450 CYP46
Term UI T000899955
Date04/27/2016
LexicalTag ABX
ThesaurusID NLM (2002); CYP46 Family
Term UI T000899829
Date04/26/2016
LexicalTag ABX
ThesaurusID NLM (2017); CYP46 Enzymes
Term UI T000899950
Date04/27/2016
LexicalTag ABX
ThesaurusID NLM (2017)

Cytochrome P450 Family 46 MeSH Descriptor Data 2023