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An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.
Entry Term(s)
4-Nitrophenol-2-Hydroxylase
CYP 2E1
CYP IIE1
CYP2E1
CYPIIE1
Cytochrome P-450 (ALC)
Cytochrome P-450 IIE1
Cytochrome P-450-J
Cytochrome P450 2E1
Dimethylnitrosamine N-Demethylase
N-Nitrosodimethylamine Demethylase
Registry Numbers
EC 1.14.13.-
Previous Indexing
Cytochrome P-450 (1975-1996)
Hydroxylases (1984-1996)
Nitrosamines (1972-1976)
Oxidoreductases (1972-1974)
Oxidoreductases, N-Demethylating (1975-1996)
Public MeSH Note
97; DIMETHYLNITROSAMINE N-DEMETHYLASE was indexed under CYTOCHROME P-450 & OXIDOREDUCTASES, N-DEMETHYLATING 1975-96, NITROSAMINES 1972-76, & OXIDOREDUCTASES 1972-74; 4-NITROPHENOL-2-HYDROXYLASE was indexed under CYTOCHROME P-450 & HYDROXYLASES 1984-96
Online Note
use CYTOCHROME P-450 CYP2E1 (NM) to search DIMETHYLNITROSAMINE N-DEMETHYLASE 1980-96 & 4-NITROPHENOL-2-HYDROXYLASE 1984-96
History Note
97; was DIMETHYLNITROSAMIME N-DEMETHYLASE (NM) 1972-96 & was 4-NITROPHENOL-2-HYDROXYLASE (NM) 1984-96
An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.