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Cytochrome P-450 CYP2E1 MeSH Descriptor Data 2021


MeSH Heading
Cytochrome P-450 CYP2E1
Tree Number(s)
D08.244.453.491.375
D08.811.682.662.582.338
D08.811.682.690.708.170.450.375
D12.776.422.220.453.491.375
Unique ID
D019392
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019392
Annotation
do not confuse with other cytochrome P-450 CYP's
Scope Note
An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.
Entry Term(s)
4-Nitrophenol-2-Hydroxylase
CYP 2E1
CYP IIE1
CYP2E1
CYPIIE1
Cytochrome P-450 (ALC)
Cytochrome P-450 IIE1
Cytochrome P-450-J
Cytochrome P450 2E1
Dimethylnitrosamine N-Demethylase
N-Nitrosodimethylamine Demethylase
Registry Number
EC 1.14.13.-
Previous Indexing
Cytochrome P-450 (1975-1996)
Hydroxylases (1984-1996)
Nitrosamines (1972-1976)
Oxidoreductases (1972-1974)
Oxidoreductases, N-Demethylating (1975-1996)
Public MeSH Note
97; DIMETHYLNITROSAMINE N-DEMETHYLASE was indexed under CYTOCHROME P-450 & OXIDOREDUCTASES, N-DEMETHYLATING 1975-96, NITROSAMINES 1972-76, & OXIDOREDUCTASES 1972-74; 4-NITROPHENOL-2-HYDROXYLASE was indexed under CYTOCHROME P-450 & HYDROXYLASES 1984-96
Online Note
use CYTOCHROME P-450 CYP2E1 (NM) to search DIMETHYLNITROSAMINE N-DEMETHYLASE 1980-96 & 4-NITROPHENOL-2-HYDROXYLASE 1984-96
History Note
97; was DIMETHYLNITROSAMIME N-DEMETHYLASE (NM) 1972-96 & was 4-NITROPHENOL-2-HYDROXYLASE (NM) 1984-96
Entry Combination
antagonists & inhibitors:Cytochrome P-450 CYP2E1 Inhibitors
Date Established
1997/01/01
Date of Entry
1996/06/24
Revision Date
2016/05/27
Cytochrome P-450 CYP2E1 Preferred
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