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Cytochrome P-450 CYP3A MeSH Descriptor Data 2023


MeSH Heading
Cytochrome P-450 CYP3A
Tree Number(s)
D08.244.453.860.500
D08.811.682.662.582.353
D08.811.682.690.708.170.495.500
D12.776.422.220.453.860.500
Unique ID
D051544
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D051544
Scope Note
A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.
Entry Term(s)
CYP3A
CYP3A4
CYP3A5
Cytochrome P-450 CYP3A4
Cytochrome P-450 CYP3A5
Cytochrome P-450IIIA
Cytochrome P450 3A
Cytochrome P450 3A4
Cytochrome P450 3A5
Erythromycin N-Demethylase
Taurochenodeoxycholate 6-alpha-Monooxygenase
Registry Number
EC 1.14.14.1
Related Numbers
EC 1.14.13.97
EC 1.14.14.1
Public MeSH Note
2006; CYTOCHROME P-450 CYP3A was indexed under ARYL HYDROCARBON HYDROXYLASES & OXIDOREDUCTASES, N-DEMETHYLATING 1980-2005
History Note
2006(1980)
Entry Combination
antagonists & inhibitors:Cytochrome P-450 CYP3A Inhibitors
Date Established
2006/01/01
Date of Entry
2005/06/30
Revision Date
2016/05/27
Cytochrome P-450 CYP3A Preferred
Cytochrome P-450 CYP3A5 Narrower
Cytochrome P-450 CYP3A4 Narrower
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