MeSH Browser

MeSH Heading: Cytochrome P-450 CYP3A
Tree Number(s): D08.244.453.860.500; D08.811.682.662.582.353; D08.811.682.690.708.170.495.500; D12.776.422.220.453.860.500
Unique ID: D051544
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D051544
Scope Note: A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.
Entry Term(s): CYP3A; CYP3A4; CYP3A5; Cytochrome P-450 CYP3A4; Cytochrome P-450 CYP3A5; Cytochrome P-450IIIA; Cytochrome P450 3A; Cytochrome P450 3A4; Cytochrome P450 3A5; Erythromycin N-Demethylase; Taurochenodeoxycholate 6-alpha-Monooxygenase
Registry Number: EC 1.14.14.1
Related Numbers: EC 1.14.13.97; EC 1.14.14.1
Public MeSH Note: 2006; CYTOCHROME P-450 CYP3A was indexed under ARYL HYDROCARBON HYDROXYLASES & OXIDOREDUCTASES, N-DEMETHYLATING 1980-2005
History Note: 2006(1980)
Entry Combination: antagonists & inhibitors:Cytochrome P-450 CYP3A Inhibitors
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2016/05/27

Entry Combination: antagonists & inhibitors:Cytochrome P-450 CYP3A Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0082919
Registry Number: EC 1.14.14.1
Related Numbers: EC 1.14.13.97; EC 1.14.14.1
Scope Note: A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.
Terms: Cytochrome P-450 CYP3A Preferred Term
Term UI T631008
Date02/18/2005
LexicalTag ABX
ThesaurusID NLM (2006); Cytochrome P-450IIIA
Term UI T112920
LexicalTag NON
ThesaurusID NLM (2006); Erythromycin N-Demethylase
Term UI T112922
LexicalTag NON
ThesaurusID NLM (2006); CYP3A
Term UI T112919
LexicalTag ACR
ThesaurusID NLM (2006); Cytochrome P450 3A
Term UI T112921
LexicalTag NON
ThesaurusID NLM (2006)

Concept UI: M0591309
Registry Number: EC 1.14.13.97
Scope Note: A specific subtype of CYP3A.
Terms: Cytochrome P-450 CYP3A4 Preferred Term
Term UI T854900
Date02/07/2014
LexicalTag ABX
ThesaurusID NLM (2015); Cytochrome P450 3A4
Term UI T854902
Date02/07/2014
LexicalTag NON
ThesaurusID NLM (2015); Taurochenodeoxycholate 6-alpha-Monooxygenase
Term UI T854903
Date02/07/2014
LexicalTag NON
ThesaurusID NLM (2015); CYP3A4
Term UI T854901
Date02/07/2014
LexicalTag ABB
ThesaurusID NLM (2015)

Cytochrome P-450 CYP3A MeSH Descriptor Data 2023