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Antidepressive Agents, Tricyclic MeSH Descriptor Data 2023


MeSH Heading
Antidepressive Agents, Tricyclic
Tree Number(s)
D27.505.954.427.700.122.055
Unique ID
D000929
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000929
Scope Note
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However, the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
Entry Term(s)
Antidepressant Drugs, Tricyclic
Antidepressants, Tricyclic
Tricyclic Antidepressant
Tricyclic Antidepressant Drug
Tricyclic Antidepressive Agent
Tricyclic Antidepressive Agents
Registry Number
0
Previous Indexing
Antidepressive Agents (1968-1974)
Public MeSH Note
75
History Note
75
Date Established
1975/09/01
Date of Entry
1974/11/11
Revision Date
2021/06/30
Antidepressive Agents, Tricyclic Preferred
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