MeSH Browser

MeSH Heading: Antidepressive Agents, Tricyclic
Tree Number(s): D27.505.954.427.700.122.055
Unique ID: D000929
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000929
Scope Note: Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However, the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
Entry Term(s): Antidepressant Drugs, Tricyclic; Antidepressants, Tricyclic; Tricyclic Antidepressant; Tricyclic Antidepressant Drug; Tricyclic Antidepressive Agent; Tricyclic Antidepressive Agents
Previous Indexing: Antidepressive Agents (1968-1974)
Public MeSH Note: 75
History Note: 75
Date Established: 1975/09/01
Date of Entry: 1974/11/11
Revision Date: 2021/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0001387
Scope Note: Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However, the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
Terms: Antidepressive Agents, Tricyclic Preferred Term
Term UI T002765
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Tricyclic Antidepressive Agent
Term UI T001008777
Date02/27/2020
LexicalTag NON
ThesaurusID NLM (2021); Tricyclic Antidepressant Drug
Term UI T001008778
Date02/27/2020
LexicalTag NON
ThesaurusID NLM (2021); Antidepressant Drugs, Tricyclic
Term UI T002766
Date04/04/1994
LexicalTag NON
ThesaurusID NLM (1995); Antidepressants, Tricyclic
Term UI T002763
Date05/04/1987
LexicalTag NON
ThesaurusID UNK (19XX); Tricyclic Antidepressive Agents
Term UI T002764
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); Tricyclic Antidepressant
Term UI T001008779
Date02/27/2020
LexicalTag NON
ThesaurusID NLM (2021)

Antidepressive Agents, Tricyclic MeSH Descriptor Data 2025